βOH-2C-B

βOH-2C-B (Beta-Hydroxy-2C-B): Analytical Research Compound Profile

βOH-2C-B, or Beta-Hydroxy-2C-B, is a novel synthetic compound structurally related to 2C-B, a well-known substituted phenethylamine. What distinguishes βOH-2C-B is the presence of a hydroxyl (-OH) group at the beta (β) position of the ethylamine side chain, which potentially alters its pharmacokinetic properties, receptor binding, and metabolic profile.

This compound is gaining traction in neurochemical and pharmacological research due to its structural novelty and close relation to 2C-B. βOH-2C-B is strictly intended for in vitro studies, analytical reference, and structure–activity relationship (SAR) research.

Chemical and Structural Information

  • Full Name: 4-Bromo-2,5-dimethoxy-β-hydroxyphenethylamine

  • Chemical Formula: C10H14BrNO3

  • Molecular Weight: 276.13 g/mol

  • IUPAC Name: 2-(4-bromo-2,5-dimethoxyphenyl)-2-hydroxyethanamine

  • Chemical Class: Substituted phenethylamine

  • Form: Typically available as a powder or crystalline solid, often as the hydrochloride salt

The addition of a beta-hydroxy group may reduce blood-brain barrier penetration compared to its non-hydroxylated counterpart (2C-B), making it a unique candidate for selective receptor targeting studies.

Research Applications

βOH-2C-B is used in a variety of scientific research domains, including:

  • 5-HT receptor binding assays, particularly 5-HT2A

  • Structure–Activity Relationship (SAR) exploration

  • Comparative analysis with 2C-B and other beta-hydroxylated analogs

  • Toxicology and forensic reference standardization

  • LC-MS and GC-MS calibration studies

  • In vitro metabolism and enzymatic degradation modeling

Its structural modifications allow researchers to evaluate how hydroxylation affects receptor selectivity, metabolic stability, and solubility.

Laboratory Characteristics

Research observations in lab conditions include:

  • Moderate to strong serotonin receptor activity (primarily 5-HT2A)

  • Enhanced hydrophilicity due to the hydroxyl group

  • Compatible with analytical instruments such as LC-MS, GC-MS, and FTIR

  • Stable under standard laboratory storage conditions when protected from light and moisture

Its beta-hydroxyl group introduces a polar moiety, which may also influence its activity duration and receptor kinetics during research.

Legal and Regulatory Status

As a novel compound, βOH-2C-B exists in a gray area legally and is often not explicitly listed in controlled substance schedules. However, it may fall under analog laws in certain jurisdictions.

  • United States: Not scheduled federally, but may be regulated under the Federal Analog Act

  • United Kingdom: May be controlled under Class A if interpreted as a 2C-B analog

  • Germany: May fall under NpSG (New Psychoactive Substances Act)

  • Canada & Australia: Legal status unclear; caution and due diligence recommended

  • EU: Varies by member state

Researchers are advised to verify the local regulatory status prior to acquisition or study.

Safe Handling and Laboratory Use

βOH-2C-B is strictly for research use only and must be handled with care in a professional laboratory setting.

Standard lab safety procedures include:

  • Use of PPE (gloves, goggles, lab coat)

  • Handling within a ventilated fume hood

  • Accurate microgram-level weighing

  • Labeled storage in airtight containers away from direct light

  • Secure access and chemical inventory tracking

  • Waste disposal in accordance with hazardous materials guidelines

For Research Use Only

βOH-2C-B is not approved for human or veterinary use. It is offered strictly for scientific, forensic, or analytical research purposes in licensed and controlled laboratory environments.

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