1cP-LSD

1cP-LSD: Lysergamide Research Chemical Profile and Legal Overview

1cP-LSD (1-cyclopropionyl-lysergic acid diethylamide) is a lysergamide research chemical structurally derived from LSD. It belongs to the same class of ergoline compounds as 1P-LSD, ALD-52, and ETH-LAD, and is studied for its potential to act as a prodrug to LSD.

Due to its close similarity to LSD in both structure and activity, 1cP-LSD is used in receptor binding studies, pharmacological modeling, and behavioral neuroscience research. It is not intended for human or veterinary use and is supplied strictly for laboratory research.

Chemical Classification and Structure

1cP-LSD is modified at the indole nitrogen with a cyclopropanecarbonyl group, which differentiates it from LSD. This substitution may alter metabolic and receptor-binding profiles, making it a valuable compound for psychedelic research and structure-activity relationship (SAR) studies.

  • IUPAC Name: (6aR,9R)-N,N-diethyl-7-methyl-4-(cyclopropanecarboxamide)-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide

  • Molecular Formula: C23H27N3O2

  • Chemical Class: Lysergamide (Ergoline derivative)

  • Physical Form: Often provided as blotters or in microgram quantities for lab analysis

  • Applications:

    • Serotonin receptor (5-HT2A) affinity studies

    • Pharmacokinetic evaluations of prodrug behavior

    • Comparative studies of lysergamide analogs

Scientific Interest and Use Cases

Although not clinically approved or studied in humans, 1cP-LSD has become a focus of academic research due to its hypothesized role as a metabolic precursor to LSD. This makes it especially useful for examining how small structural changes affect psychedelic pharmacology.

Unverified anecdotal research notes (not to be interpreted as medical data) suggest:

  • A similar effect profile to LSD with subtle variation in duration or onset

  • High potency at sub-milligram doses

  • Comparable cross-tolerance patterns with LSD and 1P-LSD

  • Stability under standard storage conditions

Such findings emphasize the compound’s value in experimental and analytical settings.

Laboratory Safety Guidelines

1cP-LSD is a potent compound and must be handled with the same care as other high-activity serotonergic agents.

Recommended safety protocols:

  • Wear gloves, goggles, and protective lab clothing

  • Use microgram-precision scales for all measurements

  • Conduct research in a controlled, licensed facility

  • Store in an airtight, light-protective container at low temperature

  • Dispose of any waste through approved chemical disposal methods

Legal Status of 1cP-LSD

Legal classification of 1cP-LSD varies by country. While it may not be explicitly scheduled, it could fall under analogue laws or psychoactive substance regulations depending on local jurisdiction.

  • United States: Unscheduled, but may be restricted under the Federal Analog Act

  • United Kingdom: Likely regulated under the Psychoactive Substances Act (PSA)

  • Germany: Controlled under the NpSG (New Psychoactive Substances Act)

  • Canada, Australia, EU: Varies between provinces and member states

Researchers are responsible for verifying local laws before purchasing or working with this compound.

For Research Use Only

1cP-LSD is not for human or animal consumption. It is provided exclusively for scientific, forensic, or analytical research by qualified personnel in professional laboratory settings.

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