1D-LSD

1D-LSD: Lysergamide Research Chemical Profile and Legal Overview

1D-LSD (1-dimethylcyclobutanoyl-lysergic acid diethylamide) is a novel lysergamide used in serotonergic and psychedelic research, structurally related to LSD and other research analogs such as 1P-LSD, 1V-LSD, and 1cP-LSD. This compound is studied for its potential prodrug activity, meaning it may convert into LSD in vivo, though this remains a subject of ongoing investigation.

Due to its structural and pharmacological similarities to LSD, 1D-LSD is of particular interest in receptor-binding studies, neuroscience, and analytical research focused on the serotonin (5-HT2A) system.

Chemical Structure and Classification

  • Full Chemical Name: 1-dimethylcyclobutanoyl-lysergic acid diethylamide

  • Molecular Formula: C25H31N3O2

  • Chemical Class: Lysergamide / Ergoline derivative

  • Appearance: Typically found in blotter or microgram powder form

  • Suggested Applications:

    • Receptor binding affinity studies

    • Prodrug metabolism analysis

    • Pharmacokinetics of lysergamides

    • Comparative psychedelic modeling

The presence of a dimethylcyclobutanoyl group at the indole nitrogen distinguishes 1D-LSD from classical LSD and other analogs, possibly altering its rate of conversion and onset in biological systems.

Research Significance

Although no formal toxicological or clinical studies exist, 1D-LSD is believed to act similarly to other LSD prodrugs. It may exhibit comparable binding affinities to serotonin receptors, particularly 5-HT2A, which is central to the study of psychedelic compounds.

Anecdotal research commentary (not peer-reviewed) has proposed:

  • LSD-like behavioral or receptor effects

  • Slight differences in potency or duration

  • Similar safety margins when handled under lab protocols

  • Unique structure for metabolic comparison to other lysergamides

These insights remain unconfirmed and are intended only for scientific discussion, not medical interpretation.

Handling and Laboratory Use

1D-LSD is a potent and active compound at microgram levels. It should only be handled by trained personnel using accurate instrumentation and appropriate laboratory safety protocols.

Lab Safety Guidelines:

  • Use of gloves, goggles, and protective clothing

  • Microgram-precision scale for dosing

  • Storage in cool, dark, and dry environments

  • Restricted access within qualified research facilities

  • Proper chemical waste disposal

Legal Status of 1D-LSD

The legal status of 1D-LSD varies by country and may fall under analogue or psychoactive substance regulations depending on national or regional laws.

  • United States: Unscheduled, but potentially regulated under the Federal Analog Act

  • Germany: 1D-LSD is legal for research use under the NpSG (as of early 2025)

  • United Kingdom: Likely covered by the Psychoactive Substances Act (PSA)

  • Switzerland & Austria: Monitoring for control but not yet explicitly scheduled

  • Other EU States: Legal status may vary — research required per jurisdiction

Researchers must confirm local laws before ordering, importing, or working with 1D-LSD.

For Research Use Only

1D-LSD is not approved for human consumption or clinical use. It is strictly intended for analytical, chemical, and academic research within certified laboratories.

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