2-FA

What Is 2-FA?

2-FA (2-Fluoroamphetamine) is a synthetic compound belonging to the phenethylamine and substituted amphetamine family. It is structurally similar to amphetamine but features a fluorine atom at the 2-position of the phenyl ring, which alters its pharmacokinetic and receptor-binding profile.

As a monoaminergic stimulant analog, 2-FA has been studied in laboratory settings for its potential interaction with dopaminergic and noradrenergic systems, making it a subject of interest in neuropharmacology and forensic toxicology.

⚠️ 2-FA is intended for laboratory research only. It is not approved for human or veterinary use.


Chemical Properties

  • IUPAC Name: 1-(2-fluorophenyl)propan-2-amine

  • Molecular Formula: C9H12FN

  • Class: Fluorinated substituted amphetamine

  • Structure: Similar to amphetamine with a fluorine substitution on the phenyl ring

  • Purity (typical research standard): ≥98%

The addition of the fluorine atom may affect lipophilicity, binding affinity, and metabolic stability, which are often areas of research focus.


Research Applications

2-FA is commonly used in non-clinical laboratory studies, including:

  • Monoamine transporter affinity testing

  • Neurochemical pathway analysis

  • SAR (Structure-Activity Relationship) modeling in CNS stimulants

  • Comparative studies with other amphetamine analogs

  • Analytical method validation using GC-MS or LC-MS techniques

Researchers often examine 2-FA’s ability to release or inhibit the reuptake of dopamine, norepinephrine, and serotonin to better understand its pharmacodynamics in experimental systems.


Legal and Regulatory Status

The legal status of 2-FA varies by country and jurisdiction:

  • United States: May be considered a controlled substance analogue under the Federal Analogue Act

  • United Kingdom: Likely controlled under the Psychoactive Substances Act

  • EU: Regulations differ by member state—check specific national controls

It is the researcher’s responsibility to ensure all procurement, handling, and use of 2-FA is compliant with local, national, and institutional laws. This compound should only be acquired for academic, analytical, or forensic research purposes.


Safe Handling & Storage

As with all potent research chemicals, 2-FA should be handled with care:

  • Wear proper PPE: gloves, lab coat, goggles

  • Storage: Keep in a cool, dry place in sealed, labeled containers

  • Labeling: Must be marked “For Research Use Only – Not for Human Consumption”

  • Disposal: Follow regulated hazardous waste protocols


Why Choose High-Grade 2-FA?

A reliable research-grade 2-FA product should meet these quality benchmarks:

  • ≥98% purity, HPLC-verified

  • Batch-specific Certificate of Analysis (COA)

  • Secure, tamper-proof, light-resistant packaging

  • Shipped with full documentation for research tracking and compliance

Reputable suppliers should never promote 2-FA for recreational or off-label use, and all documentation must reflect scientific integrity.


Summary

2-FA (2-Fluoroamphetamine) remains a compound of interest in central nervous system stimulant research, particularly in studies focused on monoamine transmission and pharmacological modeling. Its unique structure provides valuable insights into the effects of fluorination on amphetamine-like compounds.

For researchers studying CNS activity, stimulant SARs, or forensic toxicology, 2-FA offers a dependable option—when sourced and handled responsibly within a legal, lab-based framework.

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