2-FEA

What Is 2-FEA?

2-FEA (2-Fluoroethamphetamine) is a synthetic stimulant compound belonging to the phenethylamine and substituted amphetamine family, specifically as a fluorinated analogue of ethylamphetamine. It is structurally similar to 2-FA (2-Fluoroamphetamine) but includes an ethyl group at the alpha position, which may influence its potency, duration, and metabolic behavior.

In laboratory research, 2-FEA is investigated for its activity at monoamine transporters, especially regarding dopamine and norepinephrine reuptake inhibition. It has gained attention in analytical chemistry, neuropharmacology, and forensic toxicology studies.

⚠️ This compound is strictly for research use only. It is not intended for human or veterinary use.

Chemical Overview

  • IUPAC Name: 1-(2-fluorophenyl)-2-ethylamine

  • Molecular Formula: C10H14FN

  • Chemical Class: Fluorinated phenethylamine / substituted amphetamine

  • Appearance: Typically crystalline solid or fine powder (lab-grade only)

  • Purity Standard: ≥98% (HPLC-tested)

The fluorine atom at the 2-position of the phenyl ring alters 2-FEA’s interaction with biological targets compared to non-fluorinated analogues.

Research Applications

2-FEA is primarily used in controlled laboratory settings for:

  • Monoamine transporter binding studies

  • CNS stimulant structure-activity relationship (SAR) analysis

  • Toxicology and pharmacokinetic modeling

  • Analytical reference standard calibration (GC-MS, LC-MS)

  • Comparative studies of fluorinated amphetamine analogs

Because of its structural similarity to other phenethylamines, 2-FEA supports investigations into neurochemical activity, metabolism, and potential structure-driven efficacy differences.

Legal & Regulatory Status

The legal status of 2-FEA varies by jurisdiction and may be affected by analog or psychoactive substance laws.

  • United States: Not explicitly scheduled, but may fall under the Federal Analogue Act depending on intent and structural similarity to scheduled substances

  • UK & EU: Potentially restricted under analog or catch-all drug laws

  • Australia, Canada, others: Researchers should consult national registries

Researchers are fully responsible for ensuring that 2-FEA is acquired, stored, and used in accordance with all applicable laws and institutional policies.

Safe Handling Guidelines

2-FEA, like all potent research chemicals, must be handled with strict lab safety standards:

  • Personal Protective Equipment (PPE): Gloves, safety goggles, lab coat

  • Environment: Use in well-ventilated lab or fume hood

  • Storage: Store in a sealed, light-resistant container in a cool, dry place

  • Labeling: Clearly marked “For Research Use Only – Not for Human Consumption”

  • Disposal: Follow regulated chemical waste protocols

Untrained personnel should not have access to this compound under any circumstances.

Sourcing High-Grade 2-FEA

When sourcing 2-FEA for research purposes, ensure your supplier meets the following standards:

  • Batch-specific Certificate of Analysis (COA)

  • Third-party HPLC or GC-MS testing for ≥98% purity

  • Tamper-evident, compliant packaging

  • Professional support and documentation for research use

Avoid vendors that market for recreational use or provide inadequate labeling/documentation, as this indicates non-compliance and reputational risk.

Summary

2-FEA (2-Fluoroethamphetamine) is a fluorinated stimulant analog studied for its role in monoamine modulation, neuropharmacology, and forensic chemistry. With structural relevance to amphetamine-class compounds, it is a valuable molecule for laboratories examining CNS stimulant behavior and analytical reference modeling.

For researchers working in the fields of neurobiology, analytical toxicology, or SAR comparison, 2-FEA offers unique insights into the subtle effects of molecular modifications.

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