2-FMA

What Is 2-FMA?

2-FMA (2-Fluoromethamphetamine) is a synthetic stimulant from the substituted amphetamine family, closely related to methamphetamine with a fluorine atom substituted at the 2-position of the phenyl ring. This structural modification contributes to changes in its receptor binding affinity, metabolic behavior, and pharmacological profile.

2-FMA is primarily studied in laboratory settings for its central nervous system stimulant properties, particularly its interaction with dopamine and norepinephrine transporters. It has become a compound of interest in neurochemical, analytical, and forensic science research.

⚠️ 2-FMA is sold strictly for laboratory research use only. It is not intended for human or veterinary use.

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Chemical Profile

• IUPAC Name: 1-(2-fluorophenyl)-N-methylpropan-2-amine

• Molecular Formula: C10H14FN

• Molecular Weight: ~167.22 g/mol

• Chemical Class: Fluorinated substituted amphetamine

• Purity (lab-grade standard): ≥98%, typically HPLC-verified

The presence of the fluorine atom at the 2-position alters the molecule’s lipophilicity and metabolic rate, making it distinct from other amphetamines in both behavior and analytical properties.

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Research Applications

2-FMA is utilized in a range of controlled laboratory studies, such as:

• Monoamine transporter binding and inhibition studies

• CNS stimulant pharmacological modeling

• Structure-Activity Relationship (SAR) research

• Toxicological screening and metabolic pathway analysis

• Analytical reference material for forensic standards (GC-MS, LC-MS)

Due to its stimulant characteristics and structural uniqueness, 2-FMA serves as a comparative benchmark for evaluating fluorinated phenethylamines and their potential applications in therapeutic research models.

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Safety, Handling & Laboratory Use

As with any potent research chemical, 2-FMA must be handled using standard laboratory safety protocols:

• Always wear gloves, goggles, and lab coats

• Handle in a fume hood or controlled environment

• Store in a cool, dry, light-protected location in properly sealed containers

• Ensure clear labeling: “For Research Use Only – Not for Human Consumption”

• Dispose of in accordance with local chemical disposal regulations

Unauthorized handling or improper storage can pose safety and compliance risks.

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Legal and Regulatory Status

The legal status of 2-FMA varies widely depending on jurisdiction:

• United States: Not federally scheduled, but may be regulated under analogue laws

• United Kingdom: May be considered illegal under the Psychoactive Substances Act

• European Union & Australia: Varies by country; confirm with local regulations

It is the researcher’s responsibility to ensure all activities involving 2-FMA comply with national, regional, and institutional regulations.

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Why Choose High-Purity 2-FMA?

For laboratories and research institutions, high-quality 2-FMA is essential for data consistency, purity, and safety. Look for suppliers who offer:

• Batch-specific Certificate of Analysis (COA)

• ≥98% purity confirmed via GC-MS or HPLC

• Secure, tamper-proof packaging with chemical labeling

• Full documentation for import/export or institutional review

Only trusted chemical vendors should be used to ensure that 2-FMA is properly manufactured and handled with transparency and scientific accountability.

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Summary

2-FMA (2-Fluoromethamphetamine) is a well-characterized fluorinated stimulant analog used in a variety of research domains, including neuropharmacology, analytical chemistry, and forensic science. Its profile offers valuable insights into the structure-activity relationships of amphetamine derivatives and aids in developing reference models for analytical screening.

Whether your research involves CNS stimulant pathways, SAR analysis, or analytical method development, 2-FMA provides a reliable, consistent compound—when used responsibly and within all legal and institutional guidelines.