2-METHYL-AP-237 HCl

What Is 2-METHYL-AP-237 HCl?

2-METHYL-AP-237 HCl is a synthetic opioid analgesic and research chemical structurally related to AP-237, a compound originally developed in China in the 1980s. Known for its mu-opioid receptor agonist activity, 2-METHYL-AP-237 has gained attention in pharmacological and forensic research for its potent analgesic properties and unique chemical profile.

This hydrochloride salt form of 2-METHYL-AP-237 is primarily studied in neuropharmacology, receptor affinity research, and comparative opioid potency testing. It is not approved for human or veterinary use and is intended strictly for scientific investigation.

Pharmacological Effects and Research Applications

In laboratory studies, 2-METHYL-AP-237 HCl is observed to act as a selective mu-opioid receptor agonist, producing effects that may include:

  • Potent analgesia

  • Respiratory depression (dose-dependent)

  • Minimal affinity for kappa or delta receptors

  • High bioavailability in animal models

Due to its structural modification (the addition of a methyl group at the 2-position), this compound may exhibit enhanced potency or altered duration when compared to its parent compound, AP-237.

It is often used in research focusing on:

  • Opioid receptor selectivity

  • Analgesic efficacy screening

  • Tolerance and dependence models

  • In vitro receptor binding assays

Legal Status of 2-METHYL-AP-237 HCl

The legal classification of 2-METHYL-AP-237 HCl varies across jurisdictions:

  • In some countries, it may be considered unscheduled, but regulated under analogue or psychoactive substance laws.

  • In others, especially where AP-237 is controlled, 2-METHYL-AP-237 may fall under blanket opioid bans or new psychoactive substance regulations.

Researchers are solely responsible for confirming the current legal status in their country or region before sourcing or working with this compound.

Sourcing 2-METHYL-AP-237 HCl for Research

Only verified and compliant chemical suppliers should be used when sourcing 2-METHYL-AP-237 HCl. A professional vendor will:

  • Provide third-party Certificates of Analysis (COAs)

  • Clearly label the compound as “For Research Use Only”

  • Follow international shipping, handling, and documentation protocols

  • Operate within all applicable laws and regulations

Avoid any supplier that suggests the product is intended for human consumption or makes unverified efficacy claims.

Summary

2-METHYL-AP-237 HCl is a potent synthetic opioid research chemical offering significant value to studies on mu-opioid receptor pharmacology, analgesic screening, and structure-activity relationships in opioid development. Its high receptor selectivity and novel structure make it a relevant subject in preclinical investigation.

As with all research chemicals, handling should be done in controlled environments by trained professionals, in full accordance with legal requirements and ethical laboratory standards.

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