2C-B-FLY

2C-B-FLY: Research Chemical Overview

2C-B-FLY is a structurally unique compound belonging to the phenethylamine family, and more specifically, the “FLY” series of substituted benzodifurans. It is chemically derived from 2C-B, with added fused dihydrofuran rings that significantly modify its molecular dynamics and receptor interactions. This makes 2C-B-FLY of high interest in serotonin receptor affinity research, structure–activity relationship (SAR) studies, and neuropharmacological modeling.

2C-B-FLY is intended strictly for laboratory-based scientific research. It is not approved for human consumption or clinical use.

Chemical and Structural Information

  • Full Name: 6-(2-Bromophenyl)-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b’]difuran

  • Chemical Formula: C12H13BrO2

  • Molecular Weight: 269.14 g/mol

  • IUPAC Name: 8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b’]difuran-4-ylmethanamine

  • Chemical Class: Phenethylamine / Benzodifuran

  • Forms Available: Freebase or hydrochloride salt; powder or crystalline solid

The bicyclic furan system gives 2C-B-FLY a rigid structure, which can enhance receptor binding specificity and make it a suitable candidate for ligand–receptor modeling in pharmacological simulations.

Research Applications

2C-B-FLY is studied in advanced laboratory and academic settings for the following purposes:

  • 5-HT2A receptor binding affinity testing

  • Comparative pharmacology with 2C-series and FLY-series analogs

  • In vitro functional assays on serotonergic and dopaminergic pathways

  • Neurochemical mapping using modern analytical techniques

  • Forensic reference standardization

  • SAR modeling in substituted phenethylamine derivatives

Its rigid molecular conformation makes it especially valuable in computational and predictive receptor binding studies.

Laboratory Characteristics

Although no medical or clinical data is available, researchers have observed:

  • High affinity for serotonin receptors, especially 5-HT2A

  • Longer receptor interaction half-life compared to 2C-B due to structural rigidity

  • Unique ligand behavior in binding assays

  • Excellent stability under standard lab storage conditions

As with all substituted benzodifurans, strict adherence to laboratory safety and documentation protocols is required.

Legal and Regulatory Status

The legal status of 2C-B-FLY varies by region. Although not universally scheduled, it is controlled in several jurisdictions due to its structural similarity to 2C-B.

  • United States: May be considered an analog of 2C-B under the Federal Analog Act

  • United Kingdom: Likely covered under the Psychoactive Substances Act 2016

  • Germany: Controlled under the NpSG (New Psychoactive Substances Act)

  • Canada: Not specifically listed, but potentially regulated under analogue laws

  • Australia: May be considered a Schedule 9 substance

  • European Union: Legal status differs between member states

Researchers are strongly advised to confirm the compound’s status in their respective regions before ordering or handling.

Safety and Handling Protocols

2C-B-FLY is for research use only and must be handled by qualified professionals in controlled laboratory environments.

Best practices include:

  • Use of gloves, goggles, and protective clothing

  • Handling within a chemical fume hood or ventilated enclosure

  • Proper labeling, sealed storage in a cool, dry location

  • Use of precision microgram scales for accurate measurement

  • Disposal according to institutional chemical waste protocols

Detailed logs and secure inventory control are highly recommended when working with substituted phenethylamines.

For Research Use Only

2C-B-FLY is not intended for human consumption or therapeutic use. It is provided solely for scientific, analytical, and forensic research applications in certified laboratory environments.

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