2C-C

2C-C (2,5-Dimethoxy-4-chlorophenethylamine): Research Chemical Profile

2C-C is a synthetic compound in the 2C series of substituted phenethylamines. Structurally related to 2C-B and 2C-I, it contains methoxy groups at the 2- and 5- positions of the benzene ring and a chlorine atom at the 4-position, which is believed to significantly influence its pharmacological profile.

2C-C has been of interest in receptor binding studies, structure–activity relationship (SAR) research, and neurochemical modeling. It is strictly intended for laboratory-based scientific research and is not approved for human consumption or clinical use.

Chemical and Structural Information

  • Full Name: 2,5-Dimethoxy-4-chlorophenethylamine

  • Chemical Formula: C10H14ClNO2

  • Molecular Weight: 215.68 g/mol

  • IUPAC Name: 2-(4-chloro-2,5-dimethoxyphenyl)ethanamine

  • Chemical Class: Phenethylamine / Substituted amphetamine

  • Common Forms: Hydrochloride salt or freebase; typically a fine powder or crystalline solid

Its structure allows researchers to study the impact of halogen substitution on binding efficacy and receptor selectivity, particularly at the 5-HT2A and 5-HT2C serotonin receptors.

Research Applications

2C-C is primarily used in controlled laboratory environments for:

  • In vitro receptor affinity studies

  • Neurochemical mapping and simulation modeling

  • Comparative studies with related 2C-series compounds like 2C-B, 2C-I, and 2C-D

  • Structure–activity relationship (SAR) research within halogenated phenethylamines

  • Reference standard use in forensic analysis and toxicology screens

Its relatively simple structure makes it a useful compound for entry-level receptor binding assays and baseline SAR data generation.

Observed Laboratory Properties

In research settings, 2C-C has demonstrated:

  • Moderate to high serotonin receptor activity, especially at 5-HT2A sites

  • A relatively long in vitro half-life

  • Stability under normal lab storage conditions

  • Predictable behavior in mass spectrometry and HPLC analysis

Due to its similarity to more potent 2C compounds, proper caution and handling standards should be applied at all times.

Legal and Regulatory Status

The legal classification of 2C-C varies across countries. In some regions, it is directly scheduled; in others, it may be regulated under analog or psychoactive substance laws.

  • United States: May be subject to the Federal Analog Act

  • United Kingdom: Controlled as a Class A substance

  • Germany: Listed under NpSG (New Psychoactive Substances Act)

  • Canada: Not specifically listed, but may fall under analogue controls

  • Australia: Potentially regulated under Schedule 9

  • European Union: Varies by member state

Researchers must confirm the legal status in their local jurisdiction prior to acquisition or study.

Safe Handling and Storage

2C-C is for laboratory use only and must be handled according to best practices in chemical research and analysis.

Safety guidelines include:

  • Use of PPE: gloves, goggles, and lab coats

  • Handling in fume hoods or controlled air systems

  • Accurate microgram-scale weighing

  • Clearly labeled, temperature-stable storage

  • Secure inventory logging and disposal documentation

Contamination or unauthorized handling should be reported and addressed immediately.

For Research Use Only

2C-C is not intended for human consumption or therapeutic use. It is offered exclusively for scientific, forensic, and analytical research purposes.

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