2C-D

2C-D (2,5-Dimethoxy-4-methylphenethylamine): Analytical Reference Profile

2C-D, or 2,5-Dimethoxy-4-methylphenethylamine, is a synthetic molecule from the 2C family of substituted phenethylamines. Originally synthesized in the 1970s, 2C-D is structurally characterized by methoxy groups at the 2 and 5 positions of the benzene ring and a methyl group at the 4-position.

While 2C-D is most commonly referenced in psychopharmacology literature, it remains primarily used in in vitro receptor binding assays, structure–activity relationship (SAR) exploration, and analytical method development. It is not intended for human consumption and is offered solely for laboratory-based research.

Chemical and Structural Information

  • Full Name: 2,5-Dimethoxy-4-methylphenethylamine

  • Chemical Formula: C11H17NO2

  • Molecular Weight: 195.26 g/mol

  • IUPAC Name: 2-(2,5-dimethoxy-4-methylphenyl)ethanamine

  • Chemical Class: Phenethylamine / Substituted amphetamine

  • Physical Form: Typically offered as a crystalline powder or hydrochloride salt

Its minimal 4-position substitution (methyl) allows researchers to evaluate baseline serotonin receptor interactions and compare activity against more complex analogs such as 2C-B or 2C-E.

Research Applications

2C-D is a widely studied compound in academic and pharmaceutical research labs for:

  • 5-HT2A receptor binding affinity studies

  • Comparative SAR studies among 2C-series compounds

  • Functional assays in neuropharmacological modeling

  • Forensic toxicology standardization

  • LC-MS and GC-MS reference calibration

  • Pharmacophore modeling of substituted phenethylamines

Its well-documented structure and stability make it a reliable choice for early-stage pharmacological testing.

Observed Laboratory Characteristics

While no clinical data applies, studies indicate the following research observations:

  • Affinity for serotonin receptors (5-HT2A, 5-HT2C)

  • Stability under standard lab storage conditions

  • Easily ionizable structure suitable for mass spectrometry

  • Soluble in organic solvents and dilute acid solutions

Careful control and documentation are required for any experiment involving 2C-series analogs due to their psychoactive properties.

Legal and Regulatory Status

The legal status of 2C-D varies widely and may be influenced by its similarity to other scheduled substances.

  • United States: May fall under the Federal Analog Act

  • United Kingdom: Controlled under Class A of the Misuse of Drugs Act

  • Germany: Listed in the NpSG (New Psychoactive Substances Act)

  • Australia: Typically regulated under Schedule 9

  • European Union: Legal status depends on the specific member state

  • Canada: Not specifically listed, but may be controlled under analogue provisions

Always verify local laws and ensure appropriate licenses or exemptions before ordering or handling.

Handling and Laboratory Safety

2C-D is designated for research use only and must be handled by trained professionals in compliance with laboratory safety protocols.

Standard safety practices include:

  • Use of gloves, eye protection, and lab coats

  • Weighing in fume hoods or ventilated environments

  • Accurate microgram-scale measurement

  • Storage in airtight containers, away from light and moisture

  • Proper labeling and inventory tracking

  • Chemical waste disposal per institutional or governmental guidelines

For Research Use Only

2C-D is not approved for human or veterinary use. It is provided exclusively for use in scientific, forensic, or analytical research environments.

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