3-FA

What Is 3-FA?

3-FA (3-Fluoroamphetamine) is a synthetic compound from the substituted amphetamine and phenethylamine family. It features a fluorine atom on the 3-position of the phenyl ring, differentiating it from its 2-FA and 4-FA counterparts. This structural change influences the compound’s receptor binding profile, potency, and duration, making it a relevant subject of research in neurochemistry and stimulant pharmacology.

3-FA is primarily used in laboratory research settings and has no approved use in human or veterinary medicine. It is studied for its activity at monoamine transporters, particularly involving dopamine and norepinephrine pathways.

⚠️ 3-FA is supplied for laboratory research use only. It is not for human consumption or therapeutic use.

Chemical Profile

  • IUPAC Name: 1-(3-fluorophenyl)propan-2-amine

  • Molecular Formula: C9H12FN

  • Class: Fluorinated substituted amphetamine

  • Typical Purity: ≥98% (analytical grade, HPLC verified)

The fluorine substitution at the meta (3-) position makes 3-FA chemically distinct from other fluoroamphetamines, potentially impacting metabolic stability, blood-brain barrier penetration, and neurotransmitter affinity.

Laboratory Applications

3-FA has been used in controlled scientific environments to support research such as:

  • Monoamine reuptake inhibition assays

  • SAR (Structure-Activity Relationship) comparisons within fluorinated amphetamines

  • Neuropharmacological modeling of stimulant compounds

  • Toxicological and metabolic pathway profiling

  • Analytical reference calibration using LC-MS, GC-MS, or FTIR

Its unique placement of the fluorine atom allows researchers to explore how positional isomerism affects central nervous system activity and transporter specificity.

Legal & Compliance Notes

The legal status of 3-FA differs based on jurisdiction:

  • United States: May fall under analogue laws depending on context and structural similarity

  • European Union/UK: Likely subject to regulation under the Psychoactive Substances Act or national analogue controls

  • Australia, Canada, others: Laws vary — verify with relevant authorities

Researchers are responsible for ensuring that 3-FA is handled in full compliance with institutional and local regulatory requirements. Possession or use outside a research framework may be prohibited.

Safe Handling & Storage

All handling of 3-FA should follow established laboratory safety protocols:

  • Use appropriate PPE (gloves, goggles, lab coat)

  • Operate in ventilated lab or fume hood

  • Store in a light-protected, sealed container at controlled temperature

  • Label clearly: “For Research Use Only – Not for Human Consumption”

  • Dispose of waste in line with local hazardous material guidelines

Proper handling minimizes contamination, exposure, and compliance risk.

Why Researchers Choose 3-FA

Labs select 3-FA for its:

  • Structural relevance to other stimulants like amphetamine, 2-FA, and 4-FA

  • Unique fluoro-substitution, offering insight into receptor interaction differences

  • Clean analytical profile, making it suitable as a reference material

  • Stability and solubility for in vitro and analytical applications

Ensure that your 3-FA is sourced from reputable suppliers offering:

  • ≥98% purity, HPLC or GC-MS verified

  • Batch-specific Certificate of Analysis (COA)

  • Proper documentation and labeling

  • Secure, compliant packaging

Summary

3-FA (3-Fluoroamphetamine) is a fluorinated stimulant analog studied for its effects on monoaminergic systems and its structural role in substituted amphetamine research. It is a valuable compound for researchers examining SAR models, neurotransmitter systems, and toxicological profiles of stimulant analogs.

For labs seeking insights into fluorinated phenethylamine behavior, 3-FA offers a well-characterized and stable compound, when used responsibly and legally in research environments.

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