3-FEA

What Is 3-FEA?

3-FEA (3-Fluoroethamphetamine) is a synthetic stimulant compound from the phenethylamine and substituted amphetamine class. It is a fluorinated analogue of ethylamphetamine, with the fluorine atom positioned on the 3rd carbon of the aromatic ring. This configuration makes it a subject of interest for structure-activity relationship (SAR) research and monoamine transporter studies.

3-FEA has drawn attention for its similarities to other fluorinated amphetamines like 2-FEA and 4-FEA, with distinct variations in its binding affinity, duration of activity, and metabolic profile.

⚠️ 3-FEA is strictly for research purposes only. It is not approved for human or veterinary use.

Chemical Overview

  • IUPAC Name: 1-(3-fluorophenyl)-2-ethylamine

  • Molecular Formula: C10H14FN

  • Chemical Class: Fluorinated substituted amphetamines

  • Molecular Weight: ~167.22 g/mol

  • Purity: ≥98% (typical, lab-verified by HPLC or GC-MS)

This compound is typically available in fine crystalline powder form and is stable under standard laboratory storage conditions.

Research Applications

3-FEA is used in non-clinical research to explore a range of scientific areas:

  • Monoamine reuptake and transporter inhibition studies

  • Neuropharmacological modeling of stimulant compounds

  • SAR comparisons among fluorinated amphetamines

  • Toxicology and metabolism screening

  • Analytical calibration standards for LC-MS, GC-MS, and FTIR

Its structural similarity to other amphetamine analogues makes it a valuable compound for exploring how fluorine positioning affects stimulant properties.

Legal and Regulatory Considerations

The legal classification of 3-FEA varies by country and jurisdiction:

  • United States: Not scheduled at the federal level, but may be subject to analogue laws

  • United Kingdom: Likely covered under the Psychoactive Substances Act

  • EU & Australia: Legal status differs; local verification is necessary

Researchers are solely responsible for ensuring all local, institutional, and international compliance when ordering, handling, or studying 3-FEA.

Safe Handling Guidelines

To ensure safety and compliance, 3-FEA should be handled in professional laboratory settings using proper protocol:

  • Wear appropriate PPE: gloves, lab coat, eye protection

  • Work in a controlled environment: fume hood or ventilated lab space

  • Storage: Keep sealed in a dry, cool, and dark place

  • Labeling: Clearly marked as “For Research Use Only – Not for Human Consumption”

  • Disposal: According to hazardous material guidelines in your jurisdiction

Proper documentation and inventory tracking are strongly recommended for regulated lab environments.

Why Choose High-Purity 3-FEA?

When sourcing 3-FEA for scientific research, ensure you select a supplier that provides:

  • ≥98% purity (third-party verified)

  • Batch-specific Certificate of Analysis (COA)

  • Secure, tamper-evident packaging

  • Detailed product documentation and chemical identifiers

  • Professional support and compliance transparency

Using research-grade materials ensures reliable results, reproducibility, and data integrity for analytical and forensic studies.

Summary

3-FEA (3-Fluoroethamphetamine) is a structurally unique fluorinated amphetamine analog that contributes valuable insights into monoamine stimulation, neurochemical modulation, and structure-activity relationships in substituted amphetamines.

Its use in analytical chemistry, pharmacological modeling, and forensic science supports deeper exploration of how fluorine substitution at different ring positions alters chemical behavior. For laboratories seeking to expand their catalog of CNS stimulant analogs, 3-FEA is a relevant and high-value compound.

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