3-FMA

What Is 3-FMA?

3-FMA (3-Fluoromethamphetamine) is a synthetic compound in the fluorinated substituted amphetamine family, structurally related to methamphetamine with a fluorine atom in the 3-position of the phenyl ring. This slight but significant molecular adjustment alters its receptor affinity, metabolic profile, and neurochemical impact, making 3-FMA a valuable tool in laboratory and forensic science environments.

As with similar compounds like 2-FMA and 4-FMA, 3-FMA is primarily studied for its interaction with dopamine and norepinephrine transporters and its potential utility in central nervous system (CNS) research.

⚠️ 3-FMA is strictly intended for laboratory research use only. It is not for human or veterinary consumption.

Chemical Overview

  • IUPAC Name: 1-(3-fluorophenyl)-N-methylpropan-2-amine

  • Molecular Formula: C10H14FN

  • Molecular Weight: ~167.22 g/mol

  • Chemical Class: Fluorinated substituted amphetamine

  • Typical Purity: ≥98%, verified by HPLC or GC-MS

3-FMA differs from 2-FMA and 4-FMA in terms of fluorine ring positioning, offering a unique platform for studying structure-activity relationships (SAR) in stimulant analogs.

Research Applications

3-FMA is typically used in scientific and analytical studies for:

  • Monoamine transporter interaction research (DAT, NET)

  • SAR modeling of CNS stimulant analogs

  • Analytical method validation (LC-MS, GC-MS, FTIR)

  • Comparative toxicology and metabolism studies

  • Forensic reference material development

Its stimulant-like profile allows researchers to evaluate the impact of ring-substitution on behavioral and molecular pharmacology in controlled, non-clinical settings.

Legal and Regulatory Status

The legal status of 3-FMA varies across jurisdictions:

  • United States: Not federally scheduled, but may be subject to the Federal Analogue Act

  • UK & Europe: May be controlled under blanket psychoactive substance regulations

  • Canada, Australia, etc.: Subject to specific national laws

Buyers are fully responsible for verifying and complying with all local, national, and institutional regulations governing the import, storage, and use of 3-FMA.

Handling & Storage Recommendations

3-FMA is a research chemical that must be handled responsibly:

  • Use standard PPE: gloves, goggles, and lab coats

  • Work in a fume hood or well-ventilated space

  • Store in a sealed, cool, dry container away from light

  • Label clearly: “For Research Use Only – Not for Human Consumption”

  • Dispose of via licensed hazardous waste systems

Proper documentation and handling practices are essential for laboratory safety and compliance.

Why Researchers Choose 3-FMA

Research institutions and laboratories select 3-FMA for its:

  • Consistent analytical profile and purity (≥98%)

  • Structural relevance to other methamphetamine analogs

  • Differentiated fluoro-substitution at the meta-position

  • Stability under controlled storage

  • Utility in both neuropharmacology and forensic screening

Quality assurance is critical when sourcing research chemicals. Look for:

  • Verified batch COAs (Certificates of Analysis)

  • Tamper-evident, secure packaging

  • Prompt shipping with documentation

  • Ethical, research-only supplier policies

Summary

3-FMA (3-Fluoromethamphetamine) is a fluorinated CNS stimulant analog that serves as an important research tool in neurochemical analysis, SAR modeling, and forensic testing. Its unique fluorine substitution pattern provides a foundation for studying how slight chemical modifications affect stimulant potency, transporter binding, and pharmacokinetics.

For laboratories conducting advanced studies into monoaminergic pathways or analytical toxicology, 3-FMA remains a viable, high-purity compound—provided it is used responsibly, legally, and exclusively in a scientific context.

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