3-HO-PCP

3-HO-PCP: Research Chemical Profile, Structure, and Legal Classification

3-HO-PCP (3-Hydroxyphencyclidine) is a dissociative arylcyclohexylamine compound related to PCP (phencyclidine) and 3-MeO-PCP. It has been studied for its unique binding properties to NMDA receptors, with additional affinity observed at mu-opioid receptors, setting it apart from other dissociatives.

Although chemically interesting for research into receptor modulation and SAR (structure-activity relationship) studies, 3-HO-PCP is not intended for human consumption and is supplied strictly for laboratory or analytical purposes.

Chemical Structure and Properties

3-HO-PCP contains a hydroxy group at the 3-position of the phenyl ring, which alters its pharmacological interaction compared to traditional PCP analogs. This substitution may contribute to increased receptor specificity and unique dissociative profiles in test models.

  • IUPAC Name: 3-[1-(1-phenylcyclohexyl)piperidin-3-ol]

  • Molecular Formula: C17H25NO

  • Chemical Class: Arylcyclohexylamine, dissociative

  • Appearance: Off-white or white crystalline powder

  • Form: Typically available as a hydrochloride or freebase

This compound is commonly examined in receptor binding assays, pharmacological modeling, and toxicological screenings.

Reported Effects (Anecdotal)

Scientific research on 3-HO-PCP is limited, and most descriptions of its effects are anecdotal or derived from non-clinical settings. It has been noted to display dissociative properties similar to ketamine or 3-MeO-PCP, though with distinct pharmacokinetic characteristics.

Reported effects may include:

  • Dissociation from sensory and bodily awareness

  • Altered perception of time and space

  • Reduced pain sensitivity

  • Mood elevation or introspective states

  • Cognitive disruption

Some studies and reports also highlight potential partial mu-opioid receptor activity, though this remains an area of active investigation. All research must remain preclinical.

Handling, Safety, and Toxicology

The toxicology profile of 3-HO-PCP is not fully understood. As a research chemical, it must be handled only by trained laboratory personnel using appropriate safety protocols.

Potential safety concerns include:

  • Overstimulation or CNS depression (dose-dependent)

  • Impaired motor function or coordination

  • Psychological disorientation

  • Risk of neurotoxicity or unknown long-term effects

  • Inhalation or accidental exposure risks

Always use certified PPE, fume hoods, and secured storage. Avoid any unauthorized or recreational handling.

Legal Status of 3-HO-PCP

3-HO-PCP may be regulated under analog laws or psychoactive substance legislation, depending on the country.

  • United States: Not scheduled federally but may be subject to the Federal Analog Act

  • United Kingdom: May fall under the Misuse of Drugs Act (Class B) or Psychoactive Substances Act (PSA)

  • Germany: Controlled under the NpSG (New Psychoactive Substances Act)

  • Canada & Australia: May be restricted based on similarity to PCP or other dissociatives

  • European Union: Varies by country; often monitored under national NPS frameworks

Before purchase or study, verify the current regulatory status within your jurisdiction.

For Research Use Only

3-HO-PCP is strictly intended for laboratory and scientific research. It is not approved for human or animal use under any circumstances. Proper licensing, facility certification, and legal compliance are required to possess or study this compound.

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