3-MeO-PCE

3-MeO-PCE: Research Chemical Profile, Effects, and Legal Information

3-MeO-PCE (3-Methoxyeticyclidine) is a dissociative compound within the arylcyclohexylamine class, structurally related to PCE and 3-MeO-PCP. It acts primarily as an NMDA receptor antagonist, and has been of interest in neuropharmacological research involving glutamatergic signaling pathways and receptor affinity mapping.

This compound is offered strictly for scientific, forensic, or analytical research and is not intended for human or veterinary use.

Chemical Structure and Properties

3-MeO-PCE features a methoxy substitution at the 3-position of the phenyl ring and an ethyl group in place of the more common methyl chain found in related analogs. This results in changes to both its receptor profile and pharmacodynamic characteristics when studied in vitro.

  • IUPAC Name: N-Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine

  • Molecular Formula: C15H23NO

  • Chemical Class: Arylcyclohexylamine, dissociative anesthetic

  • Appearance: Typically a white or off-white crystalline powder

  • Form: Often available as a hydrochloride or freebase

Researchers may examine 3-MeO-PCE for its binding potential to NMDA, sigma, and potentially dopaminergic receptors, depending on the study focus.

Reported Effects (Anecdotal)

Though not approved for clinical or therapeutic use, anecdotal reports from research chemical forums describe 3-MeO-PCE as producing a range of dissociative and stimulating effects.

Reported effects include:

  • Dissociation and sensory detachment

  • Euphoria or elevated mood

  • Visual distortion and altered perception

  • Cognitive shifts or introspection

  • Stimulant-like energy or focus at low concentrations

These descriptions are non-clinical and should not be interpreted as medically validated. Research should remain controlled, with no in vivo testing unless approved by institutional ethics bodies.

Handling and Laboratory Safety

Due to limited toxicological data, 3-MeO-PCE must be treated with caution in laboratory environments. Safety measures are required to prevent unintentional exposure.

Recommended lab safety practices include:

  • Use of PPE: gloves, goggles, and lab coat

  • Fume hood handling for powders or solvents

  • Secure storage in labeled, tamper-proof containers

  • Proper waste disposal in accordance with hazardous chemical protocols

Only trained professionals should access or use this compound under secure research conditions.

Legal Status of 3-MeO-PCE

The legal classification of 3-MeO-PCE varies by country and jurisdiction. While not scheduled in all regions, it may be controlled under analog laws or psychoactive substance legislation.

  • United States: Unscheduled at federal level, but may be regulated under the Federal Analog Act

  • United Kingdom: Likely controlled under the Misuse of Drugs Act or Psychoactive Substances Act (PSA)

  • Germany: Regulated under the NpSG (New Psychoactive Substances Act)

  • Canada and Australia: May be subject to broad analogue or substance-specific laws

  • European Union: Varies by member state, often classified as an NPS

Always verify your local and national laws before purchasing or possessing this substance for any purpose.

For Research Use Only

3-MeO-PCE is not intended for human consumption and is offered solely for laboratory, forensic, or chemical research. It is the responsibility of the buyer to ensure proper handling, legal compliance, and ethical research standards.

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