3-MeO-PCP

-MeO-PCP: Research Chemical Overview, Effects, and Legal Status

3-MeO-PCP (3-Methoxyphencyclidine) is a dissociative compound belonging to the arylcyclohexylamine class. It is structurally related to PCP (phencyclidine) and shares similar pharmacological properties as an NMDA receptor antagonist. This compound is primarily studied for its role in glutamatergic signaling, receptor binding affinity, and structure-activity relationship (SAR) analysis.

3-MeO-PCP is strictly intended for scientific, forensic, and analytical research and is not approved for any form of human or veterinary use.

Chemical Structure and Properties

3-MeO-PCP features a methoxy group substitution at the 3-position of the phenyl ring, which differentiates it from its parent compound PCP. This modification can affect both potency and pharmacokinetics in lab-based research models.

  • IUPAC Name: 1-[1-(3-methoxyphenyl)cyclohexyl]piperidine

  • Molecular Formula: C18H27NO

  • Chemical Class: Arylcyclohexylamine

  • Form: White crystalline solid or powder

  • Common Uses: Receptor affinity studies, neuropharmacological research, forensic analysis

Due to its relative stability and receptor selectivity, 3-MeO-PCP is often selected for comparative studies alongside analogs such as 3-MeO-PCE, O-PCE, and MXE.

Reported Effects (Anecdotal)

Though not studied in human clinical trials, 3-MeO-PCP has been reported in research communities to produce effects consistent with other dissociative NMDA antagonists.

Potential effects (based on anecdotal research logs):

  • Dissociation and detachment from surroundings

  • Altered perception and temporal distortion

  • Introspective or dream-like cognitive states

  • Reduced physical coordination

  • Mild stimulant-like properties at lower concentrations

These observations are for informational purposes only and should not be interpreted as clinically validated outcomes.

Laboratory Safety and Handling

Due to its psychoactive profile and limited toxicological data, 3-MeO-PCP should be handled under strict laboratory safety standards.

Recommended safety protocols include:

  • Use of gloves, protective eyewear, and lab coats

  • Proper ventilation (fume hood) when handling powders

  • Secure storage in labeled containers

  • Disposal in accordance with hazardous waste guidelines

Researchers should consult material safety data and institutional policies before use.

Legal Status of 3-MeO-PCP

The regulatory status of 3-MeO-PCP varies significantly between countries. While not explicitly scheduled in all regions, it may be restricted under analogue laws or psychoactive substance regulations.

  • United States: Not federally scheduled but may fall under the Federal Analog Act due to its similarity to PCP

  • United Kingdom: Classified as a Class B substance under the Misuse of Drugs Act

  • Germany: Controlled under the NpSG (New Psychoactive Substances Act)

  • Canada: Potentially regulated as an analog of PCP

  • Australia: May be restricted under existing dissociative substance legislation

  • EU Nations: Legal status varies by country and may be under review

It is the researcher’s responsibility to verify local laws before purchasing, possessing, or studying this compound.

For Research Use Only

3-MeO-PCP is not for human consumption or therapeutic use. It is supplied exclusively for scientific research, forensic analysis, or chemical investigation by licensed laboratories and academic institutions.

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