3-MMA

What Is 3-MMA?

3-MMA (3-Methylmethamphetamine) is a synthetic stimulant compound from the substituted amphetamine family, structurally similar to methamphetamine with a methyl group positioned at the 3rd carbon of the phenyl ring. This slight structural change alters its pharmacological characteristics, making it valuable in research settings focused on monoaminergic system modulation.

As with many stimulant analogs, 3-MMA is studied for its interaction with dopamine, norepinephrine, and serotonin transporters, offering insights into both structure-activity relationships (SAR) and behavioral pharmacology.

⚠️ 3-MMA is strictly intended for laboratory research only. It is not for human consumption and should not be used in clinical or veterinary contexts.

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Chemical Overview

• IUPAC Name: N-methyl-1-(3-methylphenyl)propan-2-amine

• Molecular Formula: C11H17N

• Molecular Weight: ~163.26 g/mol

• Chemical Class: Substituted amphetamines

• Typical Purity: ≥98% (HPLC or GC-MS verified)

The methyl group in the meta (3) position of the phenyl ring may impact lipophilicity, metabolic stability, and receptor affinity, which are often key variables in stimulant-related research.

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Research Applications

3-MMA is used in a variety of controlled laboratory settings for:

• Monoamine transporter and reuptake inhibition studies

• Comparative SAR research across methylated amphetamines

• Toxicological screening and profiling

• Behavioral pharmacology modeling (in vitro or in vivo)

• Calibration standards for analytical instrumentation

Its clean profile and close similarity to methamphetamine make it a useful reference compound for studying chemical behavior under forensic and pharmacological models.

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Legal and Compliance Considerations

The legal status of 3-MMA varies depending on national and local regulatory frameworks:

• United States: May be treated as an analogue under the Federal Analogue Act

• United Kingdom: Likely regulated under the Psychoactive Substances Act

• EU, Canada, Australia: Subject to specific national controls

It is the researcher’s responsibility to ensure all procurement, handling, and application of 3-MMA complies with relevant laws and institutional policies.

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Handling & Safety Guidelines

3-MMA should only be handled in certified laboratory environments with proper safety protocols:

• Use standard PPE (gloves, lab coat, protective eyewear)

• Work under fume hood or controlled ventilation

• Store in a cool, dry, dark place in sealed containers

• Label clearly: “For Research Use Only – Not for Human Consumption”

• Dispose of following your institution’s hazardous waste procedures

Ensure proper documentation and tracking of all chemical inventory for audit and safety purposes.

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Why Choose 3-MMA for Research?

Researchers choose 3-MMA because of its:

• High analytical purity (≥98%)

• Structural relation to well-known stimulant analogs

• Stability under typical lab storage conditions

• Relevance in neurochemical transporter and SAR research

Quality sourcing matters. Trusted suppliers should offer:

• Batch-specific COAs (Certificates of Analysis)

• Secure and tamper-evident packaging

• Transparent product documentation

• Research-only disclaimers and shipping compliance

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Summary

3-MMA (3-Methylmethamphetamine) is a valuable stimulant analog used in analytical chemistry, neuropharmacology, and forensic research. Its methyl group substitution at the 3-position offers a unique opportunity to study how small structural variations influence monoamine activity, metabolic breakdown, and behavioral outcomes.

When handled responsibly in qualified laboratory settings, 3-MMA can support a wide range of research objectives tied to central nervous system stimulant behavior and SAR modeling.