4-AcO-DET

4-AcO-DET: Research Chemical Profile and Tryptamine Overview

4-AcO-DET (4-Acetoxy-N,N-diethyltryptamine) is a synthetic tryptamine compound of interest in neurochemical, analytical, and forensic research. As an acetylated analog of 4-HO-DET, it belongs to the broader class of 4-substituted tryptamines, known for their activity at serotonin (5-HT) receptors.

Closely related to compounds such as 4-AcO-DMT and psilocin, 4-AcO-DET is believed to act as a prodrug, meaning it may convert into the active form 4-HO-DET under specific biological conditions — a property of interest in receptor binding and pharmacokinetic studies.

Chemical Properties

  • Full Name: 4-Acetoxy-N,N-diethyltryptamine

  • Molecular Formula: C16H24N2O2

  • IUPAC Name: [3-(2-(Diethylamino)ethyl)-1H-indol-4-yl] acetate

  • Chemical Class: Tryptamine / Indolealkylamine

  • Common Form: Powder (acetate or fumarate salt)

  • Related Compounds: 4-HO-DET, 4-AcO-DMT, DET, DMT, psilocin

Research Applications

4-AcO-DET is used in laboratory and academic settings for the following purposes:

  • Receptor binding studies, particularly 5-HT2A/5-HT1A

  • Structure–activity relationship (SAR) research

  • Analytical method development (GC-MS, LC-MS, NMR)

  • Pharmacological comparison with natural tryptamines like psilocin

  • Toxicological profiling in forensic and academic labs

Its chemical structure allows researchers to investigate how acetylation affects bioavailability, receptor affinity, and metabolic pathways compared to its hydroxy counterpart (4-HO-DET).

Observed Characteristics in Lab Studies

While no clinical or approved human data exists, laboratory observations under in vitro and theoretical models include:

  • Potential serotonergic receptor activity

  • Altered molecular polarity due to acetoxy group

  • Hypothesized to convert into 4-HO-DET under certain conditions

  • Relative stability as a powdered substance vs. hydroxy analogs

All findings remain speculative and must be interpreted within a strictly academic research context.

Legal Status of 4-AcO-DET

Legal classification of 4-AcO-DET differs between jurisdictions and often depends on its structural relationship to scheduled substances.

  • United States: Not specifically scheduled, but could be considered an analog under the Federal Analog Act

  • United Kingdom: Likely covered by the Psychoactive Substances Act 2016

  • Germany: Possibly controlled under the NpSG (New Psychoactive Substances Act)

  • Canada, Australia, New Zealand: May fall under analogue or catch-all laws

  • European Union: Mixed regulation; not uniformly scheduled

It is essential to verify local laws before ordering, storing, or handling 4-AcO-DET, even for laboratory purposes.

Safety and Laboratory Handling

4-AcO-DET is not approved for human or veterinary use and should be handled only by trained professionals in controlled research environments.

Best safety practices include:

  • Use of PPE: lab coat, nitrile gloves, and protective eyewear

  • Use of microgram-accurate digital scales

  • Secure, labeled storage in low-humidity environments

  • Documentation of all experimental handling and disposal

  • Compliance with institutional and regional chemical safety regulations

For Research Use Only

4-AcO-DET is intended strictly for scientific, analytical, and forensic research purposes. It is not for human consumption, therapeutic use, or recreational application.

  • 4-AcO-DET Powder
    4-AcO-DET

    4-AcO-DET Powder

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