4-AcO-MET

4-AcO-MET: Tryptamine Research Chemical Overview

4-AcO-MET (4-Acetoxy-N-methyl-N-ethyltryptamine) is a synthetic tryptamine compound that is structurally related to psilocin (4-HO-DMT) and other 4-substituted tryptamines. It is primarily used in scientific, neurochemical, and analytical research to explore the structure–activity relationships (SAR) and receptor affinity profiles of serotonergic compounds.

Often described as a prodrug of 4-HO-MET, 4-AcO-MET is of interest for its potential conversion in biological models, and for how its acetoxy functional group affects pharmacokinetic and metabolic behaviors compared to hydroxy analogs.

Chemical Profile

  • Full Name: 4-Acetoxy-N-methyl-N-ethyltryptamine

  • Molecular Formula: C14H20N2O2

  • IUPAC Name: [3-(2-(Ethyl(methyl)amino)ethyl)-1H-indol-4-yl] acetate

  • Chemical Class: Tryptamine / Indolealkylamine

  • Structural Relation: Analog of psilocin, 4-HO-MET, and 4-AcO-DMT

  • Appearance: Usually in powder or crystalline form

  • Common Uses: For analytical, forensic, and neuropharmacological research

Scientific and Research Applications

4-AcO-MET is studied in various laboratory settings for its:

  • Serotonin receptor interactions (primarily 5-HT2A and 5-HT1A)

  • Pharmacological modeling of prodrug behavior

  • Analytical profiling using GC-MS, HPLC, NMR

  • Comparative research with psilocin analogs and natural tryptamines

  • Toxicology screenings in forensic labs

Due to its close resemblance to naturally occurring tryptamines, 4-AcO-MET provides valuable insights into synthetic modifications and their functional implications.

Observed Laboratory Characteristics

Though no clinical or peer-reviewed human studies exist, academic and theoretical models suggest:

  • Acts as a potential prodrug for 4-HO-MET

  • Possesses unique metabolic pathways due to its acetoxy group

  • May offer greater chemical stability than hydroxy analogs

  • Exhibits affinity for serotonin receptors, especially 5-HT2A

All findings are subject to validation under controlled scientific conditions.

Legal Considerations

The legal status of 4-AcO-MET can vary globally and is often determined by its similarity to scheduled compounds.

  • United States: Not explicitly scheduled but may be controlled under the Federal Analog Act

  • United Kingdom: Likely covered under the Psychoactive Substances Act 2016

  • Germany: Controlled under NpSG (New Psychoactive Substances Act)

  • EU & Canada: Legal status varies by country; researchers must verify locally

  • Australia & New Zealand: Often regulated under analog or catch-all clauses

Researchers are responsible for complying with all applicable regulations before acquiring or working with this compound.

Safety and Handling Guidelines

4-AcO-MET should only be handled by trained laboratory personnel in licensed facilities. It is not approved for human or veterinary use.

Lab handling recommendations include:

  • Use of protective gloves, goggles, and lab coats

  • Storage in airtight containers away from light and moisture

  • Precise weighing with microgram-accurate scales

  • Safe disposal procedures compliant with chemical safety regulations

For Research Use Only

4-AcO-MET is intended strictly for scientific, forensic, or analytical research. It is not for human consumption or clinical use under any circumstances.

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