4-FMA

What Is 4-FMA?

4-FMA (4-Fluoromethamphetamine) is a synthetic stimulant compound from the substituted amphetamine class, featuring a fluorine atom at the 4-position of the phenyl ring. Structurally related to methamphetamine, 4-FMA has attracted research interest for its unique monoaminergic properties and its application in analytical and neurochemical studies.

Its structural similarity to other amphetamines, such as 2-FMA and 3-FMA, makes 4-FMA a relevant compound for comparative and structure-activity relationship (SAR) research.

⚠️ This compound is intended strictly for laboratory research use only. It is not for human or animal consumption under any circumstances.

Chemical Overview

  • IUPAC Name: 1-(4-fluorophenyl)-N-methylpropan-2-amine

  • Molecular Formula: C10H14FN

  • Molecular Weight: ~167.23 g/mol

  • Chemical Class: Substituted amphetamines / Fluorinated stimulants

  • Typical Purity: ≥98% (HPLC/GC-MS confirmed)

The 4-position fluorine substitution may influence the compound’s lipophilicity, receptor binding, and metabolic profile, which are central points of analysis in neuropharmacological studies.

Research Applications

4-FMA is typically used in professional laboratory environments for research such as:

  • Monoamine transporter interaction (dopamine, norepinephrine, serotonin)

  • Neuropharmacological response modeling

  • SAR studies comparing 2-FMA, 3-FMA, and methamphetamine analogs

  • Toxicological and forensic screening development

  • Analytical method calibration using LC-MS, FTIR, and GC-MS

Its pharmacological effects in vitro make it a frequent subject in the study of central nervous system stimulant activity under strictly controlled settings.

Legal & Regulatory Status

The legal status of 4-FMA differs by region:

  • United States: Not federally scheduled, but may fall under the Federal Analogue Act

  • United Kingdom: Likely controlled under the Psychoactive Substances Act

  • European Union: Varies by member state – check local listings

  • Australia, Canada, etc.: Subject to analogue or psychoactive substance laws

It is the sole responsibility of the purchaser to ensure compliance with all local and international regulations regarding the storage and use of 4-FMA.

Handling & Storage Guidelines

Proper laboratory practices are essential when handling 4-FMA:

  • Use certified PPE: gloves, eye protection, lab coat

  • Conduct work under a fume hood or well-ventilated area

  • Store in airtight, labeled containers in a cool, dry environment

  • Must be labeled: “For Research Use Only – Not for Human Consumption”

  • Dispose of via certified hazardous waste procedures

Safety documentation (SDS) should be reviewed prior to handling.

Why Researchers Choose 4-FMA

Research institutions and analysts often select 4-FMA due to its:

  • Predictable analytical properties

  • Consistency in stimulant analog comparison studies

  • Batch-pure formulations (≥98%) with COA available

  • Long-term stability under lab storage conditions

Look for suppliers who offer:

  • Verified Certificates of Analysis (COA)

  • Tamper-evident, clearly labeled packaging

  • Quick fulfillment and scientific documentation

  • Research-only policies with legal compliance safeguards

Summary

4-FMA (4-Fluoromethamphetamine) is a stimulant analog offering valuable insight in analytical, neurochemical, and SAR research applications. Its structural profile, related to other substituted amphetamines, makes it an excellent candidate for comparative analysis within stimulant pharmacology.

When used responsibly in certified lab environments, 4-FMA supports robust research across pharmacodynamic, toxicological, and forensic domains.

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