4-MAR "ICE" Analogues

What Are 4-MAR Analogues?

4-MAR (4-Methylaminorex) analogues—often referred to as “ICE” analogues in research contexts—are a class of synthetic stimulant compounds structurally derived from aminorex, a known psychostimulant. These analogues feature subtle structural modifications to the 4-position of the aminorex ring system, significantly impacting their pharmacological activity and metabolic behavior.

Used exclusively in analytical, pharmacological, and forensic research, 4-MAR analogues are important tools for studying monoaminergic activity, neurostimulation, and structure-activity relationships (SAR) among substituted aminorex compounds.

⚠️ All 4-MAR analogues are strictly for laboratory research use only. These compounds are not for human or veterinary consumption.

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Common 4-MAR Analogues in Research

Examples of 4-Methylaminorex analogues include:

• 4-MAR (4-Methylaminorex) – the base compound

• 4-FMAR (4-Fluoromethylaminorex) – fluorinated derivative

• 4,4’-DMAR (4,4-Dimethylaminorex) – known for high activity and past forensic relevance

• Para-methylaminorex (PMAR) – methylated variant at para-position

• N-Ethylaminorex (NEAR) – ethyl substitution on nitrogen

Each of these analogues can vary in potency, receptor binding affinity, and stimulant duration, making them ideal candidates for comparative neurochemical studies.

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Chemical and Pharmacological Overview

• Base Structure: 2-amino-5-aryl-4,5-dihydro-1,3-oxazolines

• Chemical Class: Oxazoline-based stimulants

• Common Features: Chiral centers, stimulant activity, monoamine reuptake inhibition

• Purity: ≥98% (lab-tested by HPLC, GC-MS, or NMR)

The chiral nature of 4-MAR analogues may result in different enantiomeric effects, an important consideration for receptor binding studies and metabolic modeling.

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Research Applications

4-MAR analogues are widely used in:

• Monoamine transporter inhibition studies (DAT, NET, SERT)

• Structure-activity relationship (SAR) mapping of oxazoline compounds

• Comparative stimulant activity and binding affinity profiling

• Metabolite pathway analysis and forensic toxicology

• Neuropharmacological behavior modeling in vitro

They are often evaluated alongside other stimulant classes like substituted amphetamines or cathinones to assess structural influence on activity.

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Legal & Compliance Notes

The legal status of 4-MAR analogues varies by jurisdiction:

• United States: Several may be unscheduled but could be regulated under the Federal Analogue Act

• United Kingdom & EU: Covered by the Psychoactive Substances Act or analog laws

• Canada, Australia: Often controlled; consult national scheduling documents

Buyers are responsible for ensuring local compliance. These substances are for research only and must not be used in any human or animal studies.

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Safety & Handling Protocols

4-MAR analogues require professional laboratory handling under strict safety conditions:

• PPE Required: Gloves, lab coat, and protective eyewear

• Work Environment: Fume hood or ventilated lab space

• Storage: In cool, dry, and dark locations in sealed, labeled containers

• Labeling: Clearly marked as “For Research Use Only – Not for Human Consumption”

• Disposal: Through authorized hazardous chemical waste channels

Researchers should also maintain detailed documentation and chain-of-custody logs for all high-activity substances.

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Why Choose 4-MAR Analogues for Research?

Researchers studying central nervous system stimulants often choose 4-MAR analogues due to:

• Their structural novelty and SAR value

• High analytical purity (≥98%) for reproducible results

• Well-characterized behavior across monoamine systems

• Relevance in forensic toxicology and pharmacodynamic modeling

Choose a supplier that offers:

• Batch-specific Certificate of Analysis (COA)

• Secure, tamper-evident packaging

• Technical support and documentation on request

• Compliance with international shipping and regulatory requirements

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Summary

4-MAR “ICE” analogues represent a scientifically valuable class of stimulant compounds designed for neurochemical, forensic, and SAR research. With a variety of structural variations, these analogues allow researchers to investigate how small modifications impact stimulant potency, metabolic behavior, and receptor selectivity.

When handled responsibly within qualified research environments, 4-MAR analogues can provide key insights into central nervous system stimulation, monoaminergic function, and chemical structure analysis.