5-MAPB

5-MAPB: Benzofuran-Based Research Chemical Profile and Applications

5-MAPB (5-(2-methylaminopropyl)benzofuran) is a synthetic benzofuran derivative that belongs to a class of compounds structurally related to MDMA and other substituted amphetamines. Known for its entactogenic and stimulant-like properties in academic studies, 5-MAPB is primarily utilized in analytical, forensic, and pharmacological research.

As a member of the benzofuran family, 5-MAPB features a benzofuran ring in place of the typical methylenedioxy structure seen in MDMA. This structural modification influences its affinity for monoamine transporters, particularly serotonin, dopamine, and norepinephrine systems.

---

Chemical Profile

• Full Name: 5-(2-methylaminopropyl)benzofuran

• Molecular Formula: C12H15NO

• IUPAC Name: 1-(benzofuran-5-yl)-N-methylpropan-2-amine

• Chemical Class: Benzofuran / Phenethylamine analog

• Common Form: Crystalline powder

• Applications:

  • Receptor binding studies

  • Structure–activity relationship (SAR) exploration

  • Analytical standard for toxicology screens

  • Comparison with MDMA and MAPB analogs

---

Scientific Relevance and Observations

While clinical data is unavailable, 5-MAPB is frequently evaluated in in vitro and in vivo laboratory settings due to its interaction with monoamine neurotransmitter systems.

Reported characteristics in controlled environments include:

• High affinity for serotonin (5-HT) transporters

• Moderate impact on dopamine and norepinephrine uptake

• Possible entactogenic and stimulant-like responses in biological assays

• Extended duration of activity compared to MDMA in receptor binding models

Its balanced activity makes it useful for neurochemical modeling and comparison with other empathogenic compounds, especially in SAR research.

---

Laboratory Use and Safety Guidelines

Due to its potency and psychoactive potential, 5-MAPB must be handled under strict laboratory conditions and by trained professionals.

Best safety practices include:

• Proper PPE: gloves, lab coat, and eye protection

• Secure, dry, and temperature-stable storage

• Use of high-precision scales for accurate handling

• Controlled lab access and detailed recordkeeping

• Waste disposal in line with hazardous chemical standards

5-MAPB is strictly not for human or animal use under any conditions.

---

Legal Status of 5-MAPB

The legal standing of 5-MAPB varies by country and jurisdiction. Although it is not globally scheduled, many nations regulate it due to its structural and pharmacological similarity to MDMA.

• United States: Unscheduled but may be considered a Schedule I analog under the Federal Analog Act

• United Kingdom: Classified as a Class B substance under the Misuse of Drugs Act

• Germany: Controlled under the NpSG (New Psychoactive Substances Act)

• Australia, Canada, and others: Often restricted under analogue laws

• European Union: Legal status varies; subject to temporary bans in some countries

Researchers must verify regional laws before ordering or handling 5-MAPB.

---

For Research Use Only

5-MAPB is not intended for human consumption or therapeutic use. It is supplied solely for laboratory, analytical, and forensic research purposes by qualified institutions.