5-MeO-DiPT

5-MeO-DiPT (5-Methoxy-N,N-Diisopropyltryptamine): Research Chemical Profile

5-MeO-DiPT, or 5-Methoxy-N,N-Diisopropyltryptamine, is a synthetic compound from the tryptamine family, studied primarily for its interactions with serotonin receptors, as well as its role in structure–activity relationship (SAR) research. It features a methoxy group at the 5-position of the indole ring and a diisopropylated amine, distinguishing it structurally and functionally from related compounds like DMT and 5-MeO-DMT.

This compound is strictly intended for laboratory-based scientific research and analytical reference. It is not approved for human or veterinary use.

Chemical and Structural Information

  • Full Name: 5-Methoxy-N,N-Diisopropyltryptamine

  • Chemical Formula: C17H26N2O

  • Molecular Weight: 274.4 g/mol

  • IUPAC Name: N,N-di(propan-2-yl)-2-(5-methoxy-1H-indol-3-yl)ethanamine

  • Chemical Class: Tryptamine / Indolealkylamine

  • Common Forms: Freebase or fumarate salt; powdered or crystalline solid

Its structural modifications allow researchers to evaluate the effects of larger alkyl substitutions on the pharmacodynamics and metabolic behavior of tryptamine derivatives.

Research Applications

5-MeO-DiPT is used in controlled laboratory settings for:

  • Binding assays involving 5-HT2A, 5-HT2C, and 5-HT1A serotonin receptors

  • Structure–activity relationship (SAR) studies within the tryptamine class

  • Comparative pharmacology alongside other 5-MeO analogs such as 5-MeO-DMT and 5-MeO-MiPT

  • Forensic toxicology standardization

  • Neurochemical pathway exploration using in vitro techniques

  • Metabolic profiling using LC-MS or GC-MS systems

Its distinct isopropyl substitutions make it valuable in differentiating lipophilicity, enzymatic breakdown, and receptor affinity compared to smaller N-alkyl tryptamines.

Observed Laboratory Characteristics

While no approved clinical data exists, research has shown:

  • High activity at serotonin receptor sites

  • Potential for rapid receptor activation and desensitization

  • Moderate to high lipophilicity due to diisopropyl groups

  • Unique pharmacokinetic patterns that differ from simpler N,N-dimethyl analogs

All studies involving 5-MeO-DiPT must be conducted under appropriate safety protocols in qualified facilities.

Legal and Regulatory Status

The legal classification of 5-MeO-DiPT varies by jurisdiction. While not scheduled in all regions, it may fall under analog or psychoactive substance laws.

  • United States: Controlled as a Schedule I substance

  • United Kingdom: Classified as a Class A substance under the Misuse of Drugs Act

  • Germany: Controlled under the BtMG (Narcotics Act)

  • Australia: Generally treated as a Schedule 9 poison

  • Canada and EU: May be regulated or restricted based on structural analog rules

Researchers are responsible for understanding and adhering to all applicable legal requirements.

Safety and Laboratory Handling

5-MeO-DiPT is strictly for research use only. It should only be handled by qualified professionals in secure lab environments.

Safety protocols include:

  • Protective gloves, lab coats, and goggles

  • Fume hood usage for open handling

  • Cool, dry, and secure storage with proper labeling

  • Use of precision scales and microgram-sensitive balances

  • Waste disposal in compliance with chemical handling standards

Detailed lab documentation and compound traceability are strongly recommended.

For Research Use Only

5-MeO-DiPT is not intended for human consumption or therapeutic use. It is provided strictly for scientific, analytical, and forensic research.

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