5-MeO-DMT

5-MeO-DMT (5-Methoxy-N,N-Dimethyltryptamine): Research Chemical Profile

5-MeO-DMT, or 5-Methoxy-N,N-Dimethyltryptamine, is a naturally occurring and synthetic tryptamine derivative that has become a subject of significant scientific interest. This compound features a methoxy group at the 5-position of the indole ring and a dimethylated amine, placing it within the indolealkylamine family.

5-MeO-DMT is widely studied in neuropharmacology, receptor affinity testing, analytical chemistry, and comparative molecular research. It is not intended for human consumption and is offered strictly for laboratory research and forensic use.

Chemical and Structural Data

  • Full Name: 5-Methoxy-N,N-Dimethyltryptamine

  • Chemical Formula: C13H18N2O

  • Molecular Weight: 218.3 g/mol

  • IUPAC Name: 2-(5-Methoxy-1H-indol-3-yl)-N,N-dimethylethanamine

  • Chemical Class: Tryptamine / Indolealkylamine

  • Appearance: Crystalline powder or solid (freebase or salt forms)

5-MeO-DMT is structurally related to DMT but exhibits distinct pharmacological profiles due to the presence of the methoxy functional group, which significantly alters its binding characteristics and metabolic pathway.

Research and Scientific Applications

5-MeO-DMT is used in various scientific and forensic contexts. Its key research applications include:

  • Serotonin receptor interaction studies, particularly 5-HT1A and 5-HT2A

  • Structure–activity relationship (SAR) modeling

  • Comparative research alongside DMT, 5-MeO-MiPT, and bufotenine

  • In vitro and in silico receptor mapping

  • Toxicology screens and forensic reference analysis

  • Pharmacokinetics and metabolic profiling in controlled studies

Its high potency and rapid binding kinetics make 5-MeO-DMT an important molecule in receptor-focused research.

Observed Laboratory Characteristics

Research suggests the following laboratory characteristics:

  • High affinity for 5-HT2A and 5-HT1A receptors

  • Rapid onset and short duration in simulation models

  • Strong influence on serotonergic signaling pathways

  • Lipophilic with potential to cross biological membranes (in theoretical models)

Due to its potency and fast-acting nature, it must be handled with strict laboratory controls and documented precision.

Legal and Regulatory Information

The legal status of 5-MeO-DMT varies across regions. It is often regulated under analog or psychoactive substance laws:

  • United States: Controlled under Schedule I of the Controlled Substances Act

  • United Kingdom: Classified as a Class A drug

  • Germany: Restricted under BtMG (Controlled Substances Act)

  • Canada: Schedule III substance

  • Australia: Controlled under Schedule 9

  • European Union: Controlled in many member states

Researchers must verify local laws and ensure full regulatory compliance before handling or purchasing 5-MeO-DMT.

Safety and Laboratory Handling

5-MeO-DMT is strictly for research use only. All work with the substance must occur in licensed laboratories with appropriate safety measures in place.

Handling guidelines include:

  • Use of gloves, goggles, and protective laboratory wear

  • Working in fume hoods or HEPA-filtered enclosures

  • Storage in cool, dry, and labeled containment

  • Microgram-level measurement using precision scales

  • Strict recordkeeping and chemical disposal procedures

For Research Use Only

5-MeO-DMT is not for human or veterinary consumption. It is offered solely for scientific, analytical, or forensic research in qualified settings.

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