5-MeO-MiPT

5-MeO-MiPT (5-Methoxy-N-Methyl-N-Isopropyltryptamine): Research Chemical Overview

5-MeO-MiPT, or 5-Methoxy-N-methyl-N-isopropyltryptamine, is a synthetic compound from the tryptamine class, widely studied in the fields of neuropharmacology, receptor binding research, and analytical chemistry. Structurally related to other methoxylated tryptamines such as 5-MeO-DMT, this compound is known for its unique substitution pattern, including a methoxy group at the 5-position of the indole ring and a N-methyl-N-isopropyl substitution on the ethylamine side chain.

5-MeO-MiPT is not intended for human consumption and is supplied strictly for laboratory research and forensic reference purposes.

Chemical and Structural Data

  • Full Name: 5-Methoxy-N-methyl-N-isopropyltryptamine

  • Chemical Formula: C15H24N2O

  • Molecular Weight: 248.37 g/mol

  • IUPAC Name: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-methylpropan-2-amine

  • Chemical Class: Tryptamine / Indolealkylamine

  • Common Forms: Freebase or fumarate salt; crystalline or powdered

This compound’s 5-methoxy group and asymmetric amine substitutions make it particularly useful in structure–activity relationship (SAR) studies involving serotonin receptor systems.

Research Applications

5-MeO-MiPT is used in a variety of controlled research settings to explore:

  • 5-HT receptor interactions, primarily with 5-HT2A and 5-HT1A

  • Comparative pharmacological profiles with other 5-MeO tryptamines

  • Metabolite identification and breakdown pathways in vitro

  • Analytical profiling using LC-MS, GC-MS, FTIR, and NMR techniques

  • SAR modeling to evaluate molecular efficacy based on substitutions

Its N-methyl-N-isopropyl chain offers a useful contrast to dimethyl and diethyl analogs, providing insight into how alkyl substitutions affect receptor affinity and metabolic stability.

Observed Laboratory Characteristics

While no approved therapeutic or clinical data exist, research data suggests the following:

  • Affinity for serotonergic receptors, especially 5-HT2A and 5-HT1A

  • Moderate lipophilicity, suggesting potential BBB permeability in models

  • Alkylation pattern impacts metabolism and enzymatic breakdown

  • Functional selectivity, relevant in neurochemical modeling

Due to its potency and novelty, 5-MeO-MiPT must be handled with extreme care in laboratory environments.

Legal and Regulatory Status

Legal status varies globally, and researchers must comply with applicable laws when working with 5-MeO-MiPT:

  • United States: Not scheduled at the federal level, but may fall under the Federal Analog Act

  • United Kingdom: Controlled under the Psychoactive Substances Act 2016

  • Germany: Likely restricted under the NpSG (New Psychoactive Substances Act)

  • Canada and Australia: Subject to analog or psychoactive substance regulations

  • European Union: Varies by member state

Researchers must verify local and national laws before acquisition or study.

Safety and Handling Guidelines

5-MeO-MiPT is for research use only. It is not approved for human or veterinary consumption. Proper handling and safety measures are essential.

Recommended lab practices include:

  • Use of gloves, goggles, and protective clothing

  • Storage in sealed containers, in a cool and dry location

  • Working under fume hoods or controlled air systems

  • Use of precision balances for microgram-level measurements

  • Disposal according to chemical waste protocols

For Research Use Only

5-MeO-MiPT is supplied strictly for scientific, forensic, or analytical purposes. It is not intended for consumption or any use outside a controlled laboratory setting.

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