6-APB (Benzofury)

6-APB (Benzofury): Scientific Profile and Research Use Overview

6-APB, short for 6-(2-aminopropyl)benzofuran, is a benzofuran-based research chemical that has drawn scientific interest due to its entactogenic, stimulant-like, and serotonergic properties. Commonly referred to as Benzofury, 6-APB is structurally and functionally related to MDMA and MDA but features a benzofuran ring in place of the methylenedioxy bridge, resulting in unique binding affinities and pharmacodynamics.

This compound is used in analytical, neurochemical, and forensic toxicology research as a comparative agent in studies exploring the effects of psychoactive analogs.

---

Chemical Profile and Classification

• Full Name: 6-(2-aminopropyl)benzofuran

• Molecular Formula: C11H13NO

• IUPAC Name: 1-(1-benzofuran-6-yl)propan-2-amine

• Chemical Class: Benzofuran / Phenethylamine analog

• Common Forms: Powder or crystalline solid (lab grade)

• Uses:

  • Neurotransmitter receptor assays

  • Monoamine transporter research

  • Analytical reference standard

  • Structure–activity relationship (SAR) modeling

---

Scientific Interest and Research Applications

6-APB has been studied in academic and laboratory settings due to its effects on serotonin (5-HT), dopamine (DA), and norepinephrine (NE) systems. It is considered a monoamine releaser, similar in mechanism to MDMA but with distinct differences in duration, intensity, and receptor binding.

Documented research observations include:

• Increased serotonergic activity in vitro

• Prolonged half-life in receptor models

• Balanced entactogenic and stimulant effects in theoretical models

• Relevance in comparing benzofuran derivatives to phenethylamines

Because of these properties, 6-APB is often studied for toxicological profiling, neurochemical mapping, and forensic identification.

---

Handling and Safety Information

6-APB is a potent research chemical and must be handled in strict laboratory conditions by trained personnel.

Recommended safety protocols include:

• Use of personal protective equipment (PPE)

• Handling in well-ventilated, certified labs

• Storage in a cool, dry environment away from light

• Use of calibrated microgram scales for precision

• Disposal according to hazardous material regulations

6-APB is not for human or veterinary consumption. All research must comply with institutional safety standards.

---

Legal Status of 6-APB

6-APB’s legal classification varies across jurisdictions and may be regulated due to its structural similarity to controlled empathogens.

• United Kingdom: Classified as a Class B substance under the Misuse of Drugs Act

• United States: Not federally scheduled, but may fall under the Federal Analog Act

• Germany: Controlled under the NpSG (New Psychoactive Substances Act)

• Canada & Australia: Often controlled as an analog of MDMA or related substances

• EU States: Frequently restricted or subject to temporary bans

It is the researcher’s responsibility to verify legal status in their specific country or region prior to acquisition or study.

---

For Research Use Only

6-APB (Benzofury) is intended strictly for laboratory, analytical, and forensic research. It is not approved for human or veterinary use.