a-PHP

-PHP: Research Chemical Profile, Effects, and Legal Classification

a-PHP (alpha-Pyrrolidinohexanophenone) is a synthetic stimulant classified within the pyrrolidinophenone family of cathinones. Closely related to α-PVP and MDPV, a-PHP is recognized in research circles for its potent central nervous system stimulation and structurally unique features that contribute to extended activity.

Although it has appeared on the gray market, a-PHP is intended strictly for forensic, chemical, and academic research — not for human or veterinary use.

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What is a-PHP?

a-PHP is chemically similar to α-PVP, with a longer hexyl side chain, which may affect its potency, duration, and lipid solubility. It is generally studied for its role as a dopamine-norepinephrine reuptake inhibitor (DNRI) in research models, though formal pharmacological data is limited.

• IUPAC Name: 1-phenyl-2-(pyrrolidin-1-yl)hexan-1-one

• Molecular Formula: C16H23NO

• Chemical Class: Synthetic cathinone, pyrrolidinophenone

• Form: Typically available as a white or off-white crystalline powder

Its structural modifications give it potential to cross the blood-brain barrier efficiently, resulting in significant CNS activity in comparative studies.

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Reported Effects (Anecdotal & Speculative)

Because a-PHP has not undergone peer-reviewed clinical testing, most known effects are based on anecdotal reports from research environments. Observations may include:

• Mental and physical stimulation

• Increased energy and alertness

• Enhanced focus

• Reduced fatigue or appetite

• Euphoria (in reported cases)

Effects may vary depending on dose, route of administration, and purity. These observations are speculative and not backed by formal toxicological review.

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Safety Profile and Research Warnings

Due to its structural similarity to controlled stimulants like α-PVP and MDPV, a-PHP may pose significant risks if improperly handled. Safety concerns include:

• Elevated heart rate and blood pressure

• Risk of anxiety, paranoia, or overstimulation

• Potential neurotoxicity with repeated or high-dose exposure

• Unknown long-term health effects

• Risk of psychological dependence

All handling must occur in secure lab settings using appropriate personal protective equipment (PPE). a-PHP is not suitable for human consumption and should never be ingested.

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Legal Status of a-PHP

a-PHP is regulated or monitored in several countries due to its close resemblance to previously banned stimulants.

• United States: Not specifically scheduled, but may be considered illegal under the Federal Analog Act

• United Kingdom: Covered under the Psychoactive Substances Act

• Germany: Listed under the NpSG (New Psychoactive Substances Act)

• Australia, Canada, Sweden, and others: Typically controlled under local psychoactive substance laws

• EU: Subject to increased scrutiny and inclusion in emerging substance monitoring lists

Researchers should verify the legality of this compound in their region before ordering, importing, or studying it.

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For Research Use Only

a-PHP is provided solely for analytical, forensic, and academic research. It is not intended for therapeutic or recreational use. All users must comply with applicable laws and ensure safe handling practices within licensed laboratories.