AL-LAD

AL-LAD: Lysergamide Research Chemical Overview and Scientific Profile

AL-LAD (6-allyl-6-nor-lysergic acid diethylamide) is a semi-synthetic lysergamide compound structurally similar to LSD. Originally synthesized in the 1970s and later brought into focus by psychedelic researchers in the 21st century, AL-LAD has become a notable subject in serotonergic and neuropharmacological research due to its unique receptor-binding profile and behavioral characteristics.

AL-LAD is believed to act as a 5-HT2A receptor agonist, placing it within the same class of interest as LSD and other ergoline derivatives. Its subtle structural differences from LSD offer valuable insight into structure-activity relationships (SARs) within the lysergamide family.

Chemical Structure and Properties

  • Full Name: 6-Allyl-6-nor-lysergic acid diethylamide

  • Molecular Formula: C22H27N3O

  • Class: Lysergamide / Ergoline derivative

  • Common Form: Microgram-dosed blotters or powder (for lab use only)

  • Key Research Applications:

    • Receptor binding affinity studies

    • Behavioral neuroscience modeling

    • Comparative analysis with LSD and analogs

    • Analytical method validation (e.g., HPLC, GC-MS)

The allyl group at the sixth position of the ergoline ring differentiates AL-LAD from LSD, possibly affecting its onset, receptor affinity, and metabolic breakdown.

Scientific Relevance and Observations

Although no clinical trials have been conducted on AL-LAD, it is frequently used in non-human receptor assays and in vitro pharmacology. Anecdotal reports and third-party studies suggest that AL-LAD:

  • May exhibit similar or slightly reduced potency compared to LSD

  • Has a shorter onset and slightly shorter duration

  • Produces more visual and less introspective effects (in animal models and anecdotal data)

  • May display distinct interactions with serotonin receptors due to its structural variance

These characteristics make AL-LAD a valuable candidate for psychedelic structure-function research.

Safety and Laboratory Handling

AL-LAD is highly active at microgram levels, requiring rigorous laboratory handling protocols.

Best practices for lab use include:

  • Microgram-accurate scales

  • Use of gloves and eye protection

  • Storage in airtight, light-protected containers

  • Work within a controlled, ventilated lab setting

  • Proper labeling and documentation of all research activity

This compound should only be handled by professionals in licensed research facilities.

Legal Status of AL-LAD

AL-LAD’s legal classification varies globally. While it is not scheduled under the 1971 UN Convention, its status may fall under analog or blanket substance laws in some jurisdictions.

  • United States: Unscheduled, but may be regulated under the Federal Analog Act

  • United Kingdom: Likely restricted under the Psychoactive Substances Act (PSA)

  • Germany: Controlled under the NpSG (New Psychoactive Substances Act)

  • Canada & Australia: May be subject to analog scheduling

  • European Union: Legal status differs among member states

Researchers should consult local regulations prior to acquisition or study.

For Research Use Only

AL-LAD is not intended for human or veterinary use. It is provided solely for scientific, analytical, and forensic research conducted in authorized laboratory environments.

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