Bromonordiazepam

Bromonordiazepam: Analytical Reference Benzodiazepine for Research Use

Bromonordiazepam is a classical 1,4-benzodiazepine derivative that has emerged as a compound of interest in pharmacological, forensic, and analytical research. Structurally similar to diazepam and nordiazepam, it incorporates a bromine atom substitution which can significantly alter its pharmacokinetics and receptor binding profile.

It is not approved for medical use but is valued as an analytical reference standard in laboratories studying GABA-A receptor interactions, metabolite identification, and toxicological screening.

Chemical and Structural Information

  • Full Name: 7-Bromo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

  • Chemical Formula: C15H11BrN2O

  • Molecular Weight: 315.17 g/mol

  • Class: 1,4-Benzodiazepine

  • Form: Typically provided as a crystalline solid or powder (often in hydrochloride or base form)

Bromonordiazepam is a non-triazolo benzodiazepine, closely related to nordiazepam, making it suitable for comparative receptor studies and metabolite pathway tracing.

Research Applications

Bromonordiazepam is used in a variety of laboratory and academic research areas:

  • GABA-A receptor binding and modulation assays

  • LC-MS and GC-MS method development and calibration

  • Metabolite mapping in diazepine pathways

  • SAR (Structure–Activity Relationship) studies

  • Toxicology screening panels

  • Immunoassay cross-reactivity testing

Its defined structure and known reactivity help in analytical method validation and forensic casework where benzodiazepine identification is critical.

Laboratory Profile and Observations

  • Exhibits moderate to high affinity for GABA-A receptors

  • Lipophilic, with known CNS depressant activity (not for human consumption)

  • Suitable for forensic toxicology libraries

  • Demonstrates consistent spectral response in LC-MS/MS, GC-MS, and FTIR applications

  • Stable under cool, dry, and sealed storage conditions

Due to its structural similarity to medically recognized benzodiazepines, Bromonordiazepam may serve as a prodrug or metabolite analog in various research models.

Legal and Regulatory Status

Bromonordiazepam may not be explicitly scheduled in many regions, but it is structurally related to controlled substances and may fall under analog or blanket legislation.

  • United States: Not scheduled federally, but subject to Federal Analog Act considerations

  • UK & EU: May be interpreted as a derivative under local psychoactive substances regulations

  • Germany: Possibly regulated under the NpSG

  • Canada & Australia: Varies by province/state; researchers should verify legality

All researchers must ensure compliance with local laws and institutional policies before acquiring or handling this compound.

Safe Handling and Laboratory Use

Bromonordiazepam must be handled in accordance with laboratory chemical safety standards. It is a potent CNS depressant analog and should only be used by qualified professionals.

Handling protocols include:

  • Use of PPE: gloves, goggles, lab coat

  • Fume hood handling and dust containment

  • Precision microgram-scale weighing

  • Secure storage in labeled containers

  • Documentation of use and inventory tracking

  • Disposal via hazardous chemical waste stream

For Research Use Only

Bromonordiazepam is not for human or veterinary use. It is offered solely for scientific, forensic, analytical, and toxicological research purposes.

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