Bromazolam

Bromazolam: Analytical Reference Standard for Benzodiazepine Research

Bromazolam is a triazolobenzodiazepine compound that has gained prominence in recent years as a research analog within the benzodiazepine class. It is structurally similar to alprazolam and flubromazolam, and is studied for its high GABA-A receptor affinity, central nervous system (CNS) depressant properties, and its value in forensic toxicology and neurochemical profiling.

Offered as a laboratory-grade reference material, Bromazolam is intended exclusively for analytical, forensic, or in vitro research purposes.

Chemical and Structural Information

  • Full Name: 8-Bromo-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

  • Chemical Formula: C17H13BrN4

  • Molecular Weight: 369.22 g/mol

  • Class: Triazolobenzodiazepine

  • Form: Commonly supplied as a powder or crystalline solid (hydrochloride or freebase form)

Bromazolam contains a triazolo ring fused to a benzodiazepine core, a substitution known to enhance potency, onset speed, and receptor selectivity.

Research Applications

Bromazolam is used across a range of analytical and pharmacological domains, including:

  • GABA-A receptor binding studies

  • SAR (Structure–Activity Relationship) analysis of triazolobenzodiazepines

  • Forensic toxicology reference standards

  • LC-MS/MS and GC-MS calibration

  • Cross-reactivity testing in immunoassays

  • Comparative potency modeling versus known benzodiazepines

Its high binding affinity and distinct pharmacological profile make it especially useful in substance detection, analytical method development, and forensic casework.

Laboratory Properties and Considerations

In controlled environments, Bromazolam exhibits:

  • Strong modulation of GABA-A receptor subtypes

  • High oral and sublingual bioavailability (not for human use)

  • Stability under ambient storage if kept sealed and light-protected

  • Excellent chromatographic response in LC-MS and GC-MS platforms

Because of its potency, Bromazolam is typically used in low microgram or nanogram concentrations for reference purposes.

Legal and Regulatory Status

While not scheduled in all jurisdictions, Bromazolam may be regulated under analog or blanket substance laws depending on the country.

  • United States: Unscheduled federally; may be considered an analog under the Federal Analog Act

  • United Kingdom: Potentially controlled under the Psychoactive Substances Act (PSA)

  • Germany: Covered under the NpSG (New Psychoactive Substances Act)

  • Canada & Australia: May be considered controlled due to similarity to scheduled substances

Researchers must verify the compound’s legal status in their jurisdiction before procurement or analysis.

Safe Handling and Laboratory Use

Bromazolam is intended for qualified professionals operating in certified laboratory settings. Handling procedures must adhere to established chemical safety standards.

Best practices include:

  • Use of full PPE: gloves, eye protection, lab coat

  • Handling in a fume hood or ventilated workstation

  • Secure, labeled storage in temperature-controlled areas

  • Use of microgram-precision weighing equipment

  • Documentation and inventory tracking

  • Safe disposal via licensed chemical waste providers

For Research Use Only

Bromazolam is not approved for human or veterinary use. It is offered solely for scientific, forensic, and analytical research purposes in accredited laboratory environments.

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