DMC (Dimethocaine)
What Is Dimethocaine?
Dimethocaine (DMC) is a synthetic local anesthetic and cocaine analogue developed for research into monoamine reuptake inhibition and anesthetic pharmacology. Structurally, it shares similarities with cocaine, but is non-scheduled in many regions, making it a valuable reference compound in studies involving dopamine transporter interaction, local anesthesia, and structure-activity relationships (SAR).
DMC is intended strictly for scientific research purposes and is not for human or veterinary use.
Chemical Profile
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IUPAC Name: 3-(diethylamino)-2,2-dimethylpropyl 4-aminobenzoate
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Molecular Formula: C16H26N2O2
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Molecular Weight: 278.4 g/mol
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Appearance: White to off-white crystalline powder
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Typical Purity: ≥98% (confirmed via HPLC or GC-MS)
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Storage: Keep in a cool, dry, dark place; seal tightly
Dimethocaine exhibits both local anesthetic and mild stimulant activity, making it relevant for comparative studies involving traditional anesthetics and tropane-based compounds.
Research Applications
Dimethocaine is studied in controlled laboratory environments for:
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Neuropharmacological research on dopamine/norepinephrine transporters (DAT/NET)
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Local anesthetic efficacy and mechanism of action
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SAR comparisons to cocaine and lidocaine
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In vitro metabolism studies and enzyme interaction profiling
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Analytical method development using GC-MS, LC-MS, and FTIR
Its binding affinity and fast onset make it useful for exploring the pharmacokinetics and dynamics of stimulant-class anesthetics.
Legal and Compliance Notes
Dimethocaine is not scheduled under most international drug control conventions, but its legal status varies by country and may fall under analogue or psychoactive substance laws.
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United States: Not explicitly scheduled; analogue laws may apply
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UK: Potentially covered under the Psychoactive Substances Act
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EU & Canada: Legal status varies; check national guidelines
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Australia: May be restricted under customs or analog laws
Researchers must verify all local, state, and national regulations before procurement or use.
Safe Handling & Lab Use
As with all active compounds, Dimethocaine should be handled with care by trained personnel:
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Use gloves, lab coat, and eye protection at all times
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Conduct work in a well-ventilated lab or fume hood
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Clearly label all containers: “For Research Use Only – Not for Human Consumption”
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Store in a light-resistant, air-tight container
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Dispose of unused material via hazardous waste protocols
Material Safety Data Sheets (MSDS/SDS) should be reviewed and followed at all times.
Why Researchers Choose Dimethocaine
Dimethocaine is often selected by academic, pharmacological, and forensic labs due to:
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Its similarity to cocaine without the same legal restrictions
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High analytical purity for reproducibility in assays
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Its dual-action profile (stimulant + local anesthetic)
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Usefulness in forensic toxicology, neurochemistry, and SAR modeling
Choose vendors that offer:
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Batch-specific COAs (Certificate of Analysis)
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Secure, compliant packaging
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Transparent sourcing and research-only documentation
Summary
Dimethocaine (DMC) is a versatile stimulant and anesthetic research chemical that plays a key role in studies of monoamine transporters, local anesthesia mechanisms, and substituted benzoate analogues. With its structural resemblance to cocaine and well-documented pharmacology, it remains a valuable compound for neurochemical and forensic research.
Always ensure responsible handling and strict compliance with your jurisdiction’s chemical laws.
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