Fluorexetamine (FXE)

Fluorexetamine (FXE): Research Chemical Overview and Legal Classification

Fluorexetamine (FXE) is a novel compound within the arylcyclohexylamine class of dissociatives, closely related to ketamine and methoxetamine (MXE). Featuring a fluorinated phenyl ring, FXE is used in neurochemical, receptor-binding, and pharmacological research.

Its unique structural profile makes it of interest in NMDA receptor antagonist studies, especially in comparison to other dissociatives like MXE, DCK, and DMXE. Fluorexetamine is intended strictly for laboratory use and is not approved for human or veterinary consumption.

Chemical Structure and Properties

Fluorexetamine is characterized by the inclusion of a fluorine atom on the aryl group, which may influence its binding affinity, lipophilicity, and pharmacodynamics compared to non-fluorinated analogs.

  • IUPAC Name: 2-(ethylamino)-2-(3-fluorophenyl)cyclohexanone

  • Molecular Formula: C14H18FNO

  • Chemical Class: Arylcyclohexylamine, dissociative analog

  • Appearance: Typically a white crystalline powder

  • Applications: NMDA receptor studies, forensic analysis, SAR comparisons

Due to its close relation to MXE and ketamine, FXE is frequently studied in the context of receptor-targeted research and comparative pharmacology.

Reported Effects (Informal/Anecdotal Research)

Although Fluorexetamine has not undergone peer-reviewed clinical evaluation, anecdotal research reports from online communities suggest that it may exhibit similar effects to other dissociative NMDA antagonists.

Reported (unverified) characteristics include:

  • Dissociative or anesthetic-like states

  • Visual and auditory perception changes

  • Detachment from physical surroundings

  • Mild euphoria or introspection

  • Longer duration than ketamine (depending on dosage and form)

These effects are based on anecdotal data and are included for informational purposes only. No conclusions should be drawn without controlled laboratory analysis.

Laboratory Handling and Safety

FXE should only be handled by qualified researchers in professionally equipped laboratories. Due to the lack of toxicological data, precautionary protocols are strongly advised.

Standard safety measures include:

  • Use of gloves, safety goggles, and lab coat

  • Work in a ventilated fume hood or filtered enclosure

  • Accurate microgram-scale dosing

  • Proper storage in sealed, labeled containers

  • Disposal according to chemical safety regulations

All work involving FXE must follow internal institutional safety guidelines and legal compliance standards.

Legal Status of Fluorexetamine

Fluorexetamine is not currently listed as a controlled substance in many countries, but may still fall under analogue legislation or psychoactive substance regulations, especially in jurisdictions with broad bans on arylcyclohexylamines.

  • United States: Not federally scheduled; may be controlled under the Federal Analog Act

  • United Kingdom: May fall under the Psychoactive Substances Act (PSA)

  • Germany: Potentially restricted under the NpSG (New Psychoactive Substances Act)

  • Australia & Canada: Could be regulated under analog laws or dissociative controls

  • European Union: Status varies by country and subject to change

Researchers are responsible for verifying the legal status in their country before obtaining or working with FXE.

For Research Use Only

Fluorexetamine (FXE) is not for human or animal use. It is offered exclusively for forensic, analytical, or scientific research by professionals operating in legal compliance.

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