LSZ

LSZ: Lysergamide Research Chemical Profile and Scientific Overview

LSZ (Lysergic acid 2,4-dimethylazetidide) is a semi-synthetic lysergamide compound structurally related to LSD. Originally developed by David E. Nichols and his team as part of a broader effort to study psychedelic pharmacology, LSZ has since become an important molecule in receptor-binding assays and SAR (structure–activity relationship) studies involving the serotonin system.

LSZ is thought to act as a 5-HT2A receptor agonist, similar to LSD, and has been examined for its subtle differences in receptor interaction, potency, and metabolic behavior. These characteristics make it a significant research tool in the study of psychedelic neurochemistry and ergoline derivatives.

Chemical Identity and Properties

  • Full Name: (S)-(+)-Lysergic acid 2,4-dimethylazetidide

  • Molecular Formula: C20H25N3O

  • Chemical Class: Lysergamide / Ergoline derivative

  • Typical Form: Powder or blotter, dosed at microgram levels (research use only)

  • Applications:

    • Receptor binding affinity studies (5-HT2A, 5-HT1A)

    • Psychedelic SAR investigations

    • Metabolic pathway modeling

    • Comparative research with LSD and analogs

LSZ differs from LSD by the substitution of the diethylamide group with a 2,4-dimethylazetidide ring, which significantly alters its three-dimensional conformation and receptor selectivity.

Research Significance and Observations

LSZ has been reported to:

  • Display potency on par with or slightly above LSD in certain in vitro assays

  • Demonstrate high selectivity for serotonin receptors, especially 5-HT2A

  • Offer a shorter duration in some test models

  • Serve as a key molecule in understanding LSD’s pharmacophore

Though no formal human or clinical data exist, LSZ remains a valuable research molecule in understanding psychedelic action at a molecular level.

Laboratory Safety and Use

Due to its high potency and psychoactive properties, LSZ should only be handled by qualified professionals in secure laboratory environments.

Safe lab protocols include:

  • Personal protective equipment (PPE): gloves, eye protection, lab coats

  • Use of microgram-accurate digital balances

  • Storage in dark, dry, temperature-stable environments

  • Clear labeling and restricted access protocols

  • Disposal in accordance with chemical safety regulations

Legal Status of LSZ

The legal status of LSZ varies significantly by region. It is not widely scheduled, but its similarity to LSD has drawn regulatory scrutiny.

  • United States: Not specifically scheduled; may be considered an analog under the Federal Analog Act

  • United Kingdom: Class A controlled substance

  • Germany: Controlled under the NpSG

  • Canada & Australia: May be subject to analogue regulation or customs enforcement

  • EU: Mixed legality depending on country-specific legislation

Before acquiring or handling LSZ, researchers should verify its legal status within their jurisdiction.

For Research Use Only

LSZ is not intended for human consumption or clinical use. It is provided exclusively for laboratory research and forensic analysis conducted by licensed professionals.

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