MDPHP

MDPHP: Research Chemical Overview, Effects, and Legal Status

MDPHP (3′,4′-Methylenedioxy-α-pyrrolidinohexanophenone) is a synthetic stimulant from the pyrrolidinophenone subgroup within the cathinone class. Known for its structural similarity to compounds like MDPV and α-PHP, MDPHP has been the subject of growing interest in forensic toxicology and analytical research.

While it has occasionally appeared on the recreational drug market, MDPHP is not approved for human use and is strictly intended for academic and forensic laboratory applications.


What is MDPHP?

MDPHP is a modified cathinone derivative that features both a pyrrolidine ring and a methylenedioxyphenyl group, the latter of which is also present in MDMA and methylone. These features suggest potential dopaminergic and serotonergic activity, although no formal pharmacological research has confirmed its exact mechanism of action.

  • IUPAC Name: 1-(2H-1,3-Benzodioxol-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one

  • Molecular Formula: C17H23NO3

  • Chemical Class: Synthetic cathinone, pyrrolidinophenone

  • Common Form: Fine powder or crystalline solid

MDPHP is believed to function as a norepinephrine-dopamine reuptake inhibitor (NDRI), though clinical data is unavailable.


Reported Effects (Anecdotal)

Due to the limited formal research available, much of what is known about MDPHP comes from anecdotal sources and user reports. Commonly described effects include:

  • Central nervous system stimulation

  • Increased energy and focus

  • Mood elevation or euphoria

  • Suppression of appetite

  • Enhanced sociability

Reported effects are dose-dependent and vary widely between individuals. There is no approved therapeutic or clinical application for MDPHP.


Risks and Safety Information

As with other pyrrolidinophenones, MDPHP may pose serious health risks if misused or improperly handled. Potential concerns include:

  • Elevated heart rate and blood pressure

  • Restlessness or insomnia

  • Anxiety or paranoia

  • Potential neurotoxicity or overstimulation

  • Strong urge to redose (compulsive use potential)

Due to these risks, MDPHP should only be used in controlled lab settings by qualified professionals wearing appropriate PPE (personal protective equipment). It is not for human or veterinary consumption.


Legal Status of MDPHP

The legal status of MDPHP varies by country and continues to evolve as authorities monitor emerging psychoactive substances. It is often restricted due to its structural similarity to already controlled stimulants.

  • United States: May be covered under the Federal Analog Act

  • United Kingdom: Controlled under the Psychoactive Substances Act (PSA)

  • Germany: Regulated under the New Psychoactive Substances Act (NpSG)

  • Canada & Australia: Often restricted under analog or synthetic stimulant laws

  • EU: Under surveillance by EMCDDA (European Monitoring Centre for Drugs and Drug Addiction)

Researchers should check current regulations in their jurisdiction before handling or acquiring MDPHP.


For Research Use Only

MDPHP is supplied strictly for forensic, academic, and analytical research purposes. It is not approved for human or animal use and must only be handled by licensed professionals in secure, compliant laboratory environments.

Improper use, handling, or distribution may lead to serious legal and health consequences. All research must adhere to local and international laws and safety guidelines.

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