Norflurazepam

What Is Norflurazepam?

Norflurazepam (also known as Desalkylflurazepam) is a long-acting benzodiazepine metabolite, structurally related to compounds such as flurazepam and diazepam. Unlike many benzodiazepines, Norflurazepam is not widely marketed on its own, but often appears as an active metabolite of other benzodiazepines, making it highly relevant in forensic and metabolic research.

Its strong affinity for GABA-A receptors and extended half-life make it a frequent subject in studies involving drug metabolism, receptor binding duration, and comparative CNS depressant effects.

Research Uses and Pharmacological Effects

In a laboratory context, Norflurazepam is studied for:

  • Long-acting anxiolytic and sedative effects

  • GABA-A receptor modulation and neuroinhibition

  • Comparative half-life profiling

  • Role as a primary or secondary metabolite in multi-stage benzodiazepine metabolism

Its pharmacological effects typically include:

  • Muscle relaxation

  • Anti-anxiety properties

  • Minimal hypnotic or amnesic effects at low doses

  • Very long duration, making it ideal for extended-release studies

Norflurazepam is considered less sedating than other benzodiazepines, making it of interest in low-sedation anxiolytic research.

Legal Status of Norflurazepam

Norflurazepam’s legal classification varies by region:

  • In some countries, it is unscheduled, but controlled under analogue acts or psychoactive substance legislation.

  • In others, it is explicitly scheduled, especially where related compounds like flurazepam are regulated.

Researchers must confirm the legal status in their jurisdiction before sourcing or handling Norflurazepam. It is intended for laboratory and research use only, not for human or veterinary consumption.

Sourcing Norflurazepam for Research

When sourcing Norflurazepam online, only trusted chemical suppliers should be used. Reputable vendors will:

  • Provide third-party lab testing results and Certificates of Analysis (COAs)

  • Clearly label the product as “For Research Use Only”

  • Ensure compliance with shipping and import/export regulations

  • Maintain clear traceability and documentation on chemical identity

Suppliers who market Norflurazepam for personal or recreational use should be avoided, as this undermines safety and legal compliance.

Summary

Norflurazepam is a valuable compound in benzodiazepine metabolism and pharmacology research, particularly for its extended half-life, strong receptor binding, and role as a common metabolite. It is especially relevant in toxicological, forensic, and time-release pharmacokinetics studies.

As with all research chemicals, handling Norflurazepam requires strict adherence to ethical standards, legal compliance, and laboratory safety protocols. When sourced responsibly and used correctly, it offers valuable insights into long-acting anxiolytic compounds and their behavior in the central nervous system.

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