O-PCE

O-PCE (Eticyclidine): Dissociative Research Chemical Profile and Legal Status

O-PCE, also known as Eticyclidine or 2-Oxo-PCE, is a dissociative research chemical in the arylcyclohexylamine class. Structurally related to ketamine and 3-MeO-PCP, O-PCE is studied for its activity as a non-competitive NMDA receptor antagonist, a property common to many dissociatives in this family.

O-PCE is used in laboratory settings to investigate glutamatergic system modulation, neurochemical receptor activity, and structure-activity relationships (SARs). It is not intended for human consumption and is supplied strictly for research purposes.

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Chemical Overview

O-PCE differs from other arylcyclohexylamines primarily by its ethyl substitution at the amine position and its 2-oxo ketone group. These changes influence its binding affinity and onset profile, making it valuable in pharmacological studies of NMDA receptor function and dissociative agents.

• IUPAC Name: N-Ethyldeschloroketamine / 2-(ethylamino)-2-phenylcyclohexanone

• Molecular Formula: C14H21NO

• Chemical Class: Arylcyclohexylamine, dissociative anesthetic analog

• Appearance: Typically white or off-white crystalline powder

• Research Uses: NMDA receptor binding studies, SAR development, analytical reference

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Reported Properties (Anecdotal Research Use Only)

O-PCE has not undergone formal toxicological or clinical evaluation, but anecdotal data from independent researchers suggest a dissociative effect profile similar to ketamine or 3-MeO-PCP, with a distinct balance between stimulation and dissociation.

Unverified observations include:

• Long-lasting dissociation and cognitive detachment

• Altered spatial and temporal perception

• Subtle euphoria or introspection at certain doses

• Stronger and longer-lasting than ketamine

• Possible delayed onset or lingering after-effects

These effects are based on informal research notes and should not be interpreted as medical or scientific conclusions.

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Laboratory Safety and Handling

As a novel dissociative with limited toxicological history, O-PCE must be handled under strict laboratory protocols to ensure safety and accuracy in research outcomes.

Recommended safety guidelines:

• Always wear gloves, goggles, and a protective lab coat

• Conduct all work in a ventilated or fume-controlled area

• Use calibrated scales for accurate microgram measurements

• Store securely in properly labeled containers, away from moisture and heat

• Dispose of chemical waste according to local regulations

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Legal Status of O-PCE

O-PCE’s legal classification varies by region. Although not always explicitly scheduled, it may fall under analogue laws or psychoactive substance regulations depending on the country.

• United States: Not federally scheduled; may be subject to the Federal Analog Act

• United Kingdom: Likely controlled under the Psychoactive Substances Act (PSA)

• Germany: Controlled under the NpSG (New Psychoactive Substances Act)

• Canada & Australia: Possibly considered an analog of ketamine

• EU: Legal status differs between member states

Researchers must confirm all legal restrictions applicable in their jurisdiction before obtaining or handling O-PCE.

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For Research Use Only

O-PCE (Eticyclidine) is not intended for human or veterinary use. It is offered exclusively for scientific, forensic, and analytical research by qualified professionals operating in compliance with relevant laws and safety standards.