Pyrazolam

What Is Pyrazolam?

Pyrazolam is a short-acting benzodiazepine derivative developed in the early 1970s but never marketed for therapeutic use. Unlike many benzodiazepines, Pyrazolam is not metabolized into active compounds and has minimal sedative or hypnotic effects, making it unique among GABAergic modulators.

It belongs to the triazolobenzodiazepine class and is structurally similar to alprazolam and bromazepam, but it exhibits a pharmacological profile characterized by anxiolytic effects with reduced cognitive or motor impairment. This makes it a frequent subject in pharmacodynamic, receptor binding, and behavioral studies.

Research Uses and Pharmacological Effects

Pyrazolam is primarily studied in relation to its selective GABA-A receptor modulation. In a controlled laboratory environment, it may demonstrate:

  • Anxiolytic (anti-anxiety) properties

  • Low sedation compared to similar compounds

  • Minimal amnesic or hypnotic effects

  • A favorable safety margin in dose-dependent studies

Because it does not undergo hepatic metabolism into active metabolites, Pyrazolam is often used in research focusing on unchanged renal excretion, half-life evaluation, and clearance rates.

Legal Status of Pyrazolam

The legal status of Pyrazolam depends on regional regulation:

  • In the United Kingdom, it is classified as a Class C controlled substance.

  • In many other jurisdictions, it may remain unscheduled, though still subject to analogue legislation or import restrictions.

Researchers should always verify local laws and restrictions before purchasing or handling Pyrazolam. It is not approved for medical or veterinary use and should only be handled in licensed research environments.

Buying Pyrazolam for Research

When purchasing Pyrazolam for laboratory or analytical use, it is essential to select reputable suppliers who meet legal and scientific standards. Trustworthy vendors will:

  • Provide up-to-date Certificates of Analysis (COAs)

  • Perform third-party testing for identity and purity

  • Clearly label all compounds as “For Research Use Only”

  • Follow all regulatory guidelines for packaging, storage, and shipping

Avoid any supplier that implies human consumption or misrepresents the nature of the product.

Summary

Pyrazolam is a research-grade benzodiazepine valued for its non-sedating anxiolytic profile and lack of active metabolites. It plays an important role in scientific research focused on short-acting benzodiazepines, receptor selectivity, and renal elimination pathways.

When handled responsibly and legally, Pyrazolam contributes to the broader understanding of benzodiazepine pharmacodynamics. Researchers should ensure full compliance with local laws, safety protocols, and ethical sourcing standards.

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